ENSG00000026025


Homo sapiens

Features
Gene ID: ENSG00000026025
  
Biological name :VIM
  
Synonyms : P08670 / VIM / vimentin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p13
Gene start: 17228259
Gene end: 17237593
  
Corresponding Affymetrix probe sets: 1555938_x_at (Human Genome U133 Plus 2.0 Array)   201426_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000489830
Ensembl peptide - ENSP00000224237
Ensembl peptide - ENSP00000490509
Ensembl peptide - ENSP00000431702
Ensembl peptide - ENSP00000446007
Ensembl peptide - ENSP00000435613
NCBI entrez gene - 7431     See in Manteia.
OMIM - 193060
RefSeq - XM_006717500
RefSeq - NM_003380
RefSeq Peptide - NP_003371
swissprot - A0A1B0GTT5
swissprot - B0YJC5
swissprot - A0A1B0GVG8
swissprot - P08670
swissprot - V9HWE1
swissprot - B0YJC4
Ensembl - ENSG00000026025
  
Related genetic diseases (OMIM): 116300 - Cataract 30, pulverulent, 116300
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vimENSDARG00000010008Danio rerio
 vimlENSDARG00000044501Danio rerio
 VIMENSGALG00000008677Gallus gallus
 VimENSMUSG00000026728Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DES / desmin / P17661ENSG0000017508462
PRPH / P41219 / peripherinENSG0000013540657
GFAP / P14136 / glial fibrillary acidic proteinENSG0000013109548
INA / Q16352 / internexin neuronal intermediate filament protein alphaENSG0000014879846
NEFL / P07196 / neurofilament lightENSG0000027758643
NEFM / P07197 / neurofilament mediumENSG0000010472242
NEFH / P12036 / neurofilament heavyENSG0000010028538
LMNB2 / Q03252 / lamin B2ENSG0000017661928
LMNB1 / P20700 / lamin B1ENSG0000011336825
LMNA / P02545 / lamin A/CENSG0000016078925


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR006821  Intermediate filament head, DNA-binding domain
 IPR018039  Intermediate filament protein, conserved site
 IPR027699  Vimentin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0014002 astrocyte development IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030049 muscle filament sliding TAS
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IMP
 biological_processGO:0043488 regulation of mRNA stability IMP
 biological_processGO:0045103 intermediate filament-based process IEA
 biological_processGO:0045109 intermediate filament organization IEA
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0060020 Bergmann glial cell differentiation IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0070307 lens fiber cell development IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IDA
 molecular_functionGO:0005212 structural constituent of eye lens IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0097110 scaffold protein binding IPI
 molecular_functionGO:1990254 keratin filament binding IPI


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins
Striated Muscle Contraction
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0001115 Posterior polar cataract "A `polar cataract` (HP:0010696) that affects the `posterior pole of the lens` (FMA:58898)." [HPO:probinson]
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 HP:0003577 Onset at birth 
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 HP:0007657 Cataract, nuclear diffuse nonprogressive 
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 HP:0010693 Pulverulent Cataract "A kind of `congenital cataract` (HP:0000519) that is characterized by a hollow sphere of punctate opacities involving the fetal nucleus and that usually occurs bilaterally." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138794 CASP6 / P55212 / caspase 6  / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / reaction
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000165806 CASP7 / P55210 / caspase 7  / reaction






 

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