ENSG00000061273


Homo sapiens

Features
Gene ID: ENSG00000061273
  
Biological name :HDAC7
  
Synonyms : HDAC7 / histone deacetylase 7 / Q8WUI4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.11
Gene start: 47782722
Gene end: 47833132
  
Corresponding Affymetrix probe sets: 217937_s_at (Human Genome U133 Plus 2.0 Array)   236326_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400811
Ensembl peptide - ENSP00000482003
Ensembl peptide - ENSP00000449171
Ensembl peptide - ENSP00000448532
Ensembl peptide - ENSP00000448448
Ensembl peptide - ENSP00000448305
Ensembl peptide - ENSP00000447191
Ensembl peptide - ENSP00000446538
Ensembl peptide - ENSP00000412155
Ensembl peptide - ENSP00000411058
Ensembl peptide - ENSP00000410068
Ensembl peptide - ENSP00000404394
Ensembl peptide - ENSP00000403149
Ensembl peptide - ENSP00000401872
Ensembl peptide - ENSP00000080059
Ensembl peptide - ENSP00000351326
Ensembl peptide - ENSP00000369984
Ensembl peptide - ENSP00000387792
Ensembl peptide - ENSP00000388561
Ensembl peptide - ENSP00000389501
Ensembl peptide - ENSP00000390415
Ensembl peptide - ENSP00000396159
Ensembl peptide - ENSP00000397236
NCBI entrez gene - 51564     See in Manteia.
OMIM - 606542
RefSeq - NM_001308090
RefSeq - NM_015401
RefSeq - XM_017019455
RefSeq - XM_011538481
RefSeq - XM_011538482
RefSeq - NM_001098416
RefSeq - XM_011538478
RefSeq - XM_011538479
RefSeq - XM_011538480
RefSeq Peptide - NP_001295019
RefSeq Peptide - NP_056216
RefSeq Peptide - NP_001091886
swissprot - H0YH91
swissprot - H0YHJ5
swissprot - C9JZ79
swissprot - H0YI41
swissprot - J3KPH8
swissprot - Q8WUI4
swissprot - H0YI15
swissprot - C9JVZ1
swissprot - C9JNI4
swissprot - C9JKN3
swissprot - C9JH46
swissprot - C9JGF5
swissprot - C9JF80
swissprot - C9JEB6
swissprot - C9JBC2
swissprot - C9JAH2
swissprot - C9J102
swissprot - A0A087WYQ4
swissprot - F8VWY3
Ensembl - ENSG00000061273
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01074076.1ENSDARG00000105179Danio rerio
 hdac7bENSDARG00000073850Danio rerio
 HDAC7ENSGALG00000039710Gallus gallus
 Hdac7ENSMUSG00000022475Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HDAC4 / P56524 / histone deacetylase 4ENSG0000006802452
HDAC5 / Q9UQL6 / histone deacetylase 5ENSG0000010884045
HDAC9 / Q9UKV0 / histone deacetylase 9ENSG0000004805245
HDAC6 / Q9UBN7 / histone deacetylase 6ENSG0000009463124
HDAC10 / Q969S8 / histone deacetylase 10ENSG0000010042911


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR017320  Histone deacetylase class II, eukaryotic
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007043 cell-cell junction assembly IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0032703 negative regulation of interleukin-2 production IDA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IMP
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity TAS
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IPI
 molecular_functionGO:0071889 14-3-3 protein binding IDA


Pathways (from Reactome)
Pathway description
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
SUMOylation of DNA damage response and repair proteins
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112333 NR2E1 / Q9Y466 / nuclear receptor subfamily 2 group E member 1  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr