ENSG00000065526


Homo sapiens

Features
Gene ID: ENSG00000065526
  
Biological name :SPEN
  
Synonyms : Q96T58 / SPEN / spen family transcriptional repressor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.21
Gene start: 15847864
Gene end: 15940460
  
Corresponding Affymetrix probe sets: 1556058_s_at (Human Genome U133 Plus 2.0 Array)   1556059_s_at (Human Genome U133 Plus 2.0 Array)   201996_s_at (Human Genome U133 Plus 2.0 Array)   201997_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388021
Ensembl peptide - ENSP00000400914
Ensembl peptide - ENSP00000364912
NCBI entrez gene - 23013     See in Manteia.
OMIM - 613484
RefSeq - NM_015001
RefSeq Peptide - NP_055816
swissprot - Q96T58
swissprot - F6WRY4
swissprot - H0Y5U7
Ensembl - ENSG00000065526
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch1073-335m2.2ENSDARG00000074332Danio rerio
 spenENSDARG00000074245Danio rerio
 SPENENSGALG00000036932Gallus gallus
 SpenENSMUSG00000040761Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RBM15 / Q96T37 / RNA binding motif protein 15ENSG000001627757
Q8NDT2 / RBM15B / RNA binding motif protein 15BENSG000002599565


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR010912  Spen paralogue/orthologue C-terminal, metazoa
 IPR012921  Spen paralogue and orthologue SPOC, C-terminal
 IPR016194  SPOC-like, C-terminal domain superfamily
 IPR034172  SHARP, RNA recognition motif 1
 IPR034173  SHARP, RNA recognition motif 2
 IPR034174  SHARP, RNA recognition motif 3
 IPR034175  SHARP, RNA recognition motif 4
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000398 mRNA splicing, via spliceosome IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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