ENSG00000067369


Homo sapiens

Features
Gene ID: ENSG00000067369
  
Biological name :TP53BP1
  
Synonyms : Q12888 / TP53BP1 / tumor protein p53 binding protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.3
Gene start: 43403061
Gene end: 43510728
  
Corresponding Affymetrix probe sets: 1569097_at (Human Genome U133 Plus 2.0 Array)   1569098_s_at (Human Genome U133 Plus 2.0 Array)   203050_at (Human Genome U133 Plus 2.0 Array)   213266_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413010
Ensembl peptide - ENSP00000398508
Ensembl peptide - ENSP00000416212
Ensembl peptide - ENSP00000471624
Ensembl peptide - ENSP00000263801
Ensembl peptide - ENSP00000371470
Ensembl peptide - ENSP00000371475
Ensembl peptide - ENSP00000388028
Ensembl peptide - ENSP00000392048
Ensembl peptide - ENSP00000393497
NCBI entrez gene - 7158     See in Manteia.
OMIM - 605230
RefSeq - XM_017022533
RefSeq - NM_001141979
RefSeq - NM_001141980
RefSeq - NM_005657
RefSeq - XM_011521985
RefSeq - XM_011521986
RefSeq Peptide - NP_001135452
RefSeq Peptide - NP_005648
RefSeq Peptide - NP_001135451
swissprot - C9JXV0
swissprot - H7BZY0
swissprot - H7C151
swissprot - H7C3N7
swissprot - M0R142
swissprot - H7C495
swissprot - Q12888
swissprot - A6NNK5
Ensembl - ENSG00000067369
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tp53bp1ENSDARG00000079000Danio rerio
 TP53BP1ENSGALG00000042201Gallus gallus
 P70399ENSMUSG00000043909Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR014722  Ribosomal protein L2, domain 2
 IPR015125  Tumour suppressor p53-binding protein-1 Tudor domain
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0045830 positive regulation of isotype switching IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IC
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000781 chromosome, telomeric region IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0035861 site of double-strand break IDA
 cellular_componentGO:1990391 DNA repair complex IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0061649 ubiquitin modification-dependent histone binding IDA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000011485 PPP5C / P53041 / protein phosphatase 5 catalytic subunit  / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / reaction / complex
 ENSG00000080345 RIF1 / Q5UIP0 / replication timing regulatory factor 1  / complex / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / reaction / complex
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / reaction / complex
 ENSG00000183765 CHEK2 / O96017 / checkpoint kinase 2  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / complex / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / complex / reaction
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / complex / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000157212 PAXIP1 / Q6ZW49 / PAX interacting protein 1  / reaction / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / complex / reaction
 ENSG00000163322 Q6UWZ7 / ABRAXAS1 / abraxas 1, BRCA1 A complex subunit  / reaction / complex
 ENSG00000196419 XRCC6 / P12956 / X-ray repair cross complementing 6  / reaction
 ENSG00000152457 Q96SD1 / DCLRE1C / DNA cross-link repair 1C  / complex / reaction
 ENSG00000079246 XRCC5 / P13010 / X-ray repair cross complementing 5  / reaction
 ENSG00000087206 UIMC1 / Q96RL1 / ubiquitin interaction motif containing 1  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr