Manteia

ENSG00000067560

Homo sapiens

Features

Gene ID:	ENSG00000067560

Biological name :	RHOA

Synonyms :	P61586 / ras homolog family member A / RHOA

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	3
Strand:	-1
Band:	p21.31
Gene start:	49359145
Gene end:	49412998

Corresponding Affymetrix probe sets:	1555814_a_at (Human Genome U133 Plus 2.0 Array) 200059_s_at (Human Genome U133 Plus 2.0 Array) 240337_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000394483 Ensembl peptide - ENSP00000413587 Ensembl peptide - ENSP00000408402 Ensembl peptide - ENSP00000400175 NCBI entrez gene - 387 See in Manteia. OMIM - 165390 RefSeq - NM_001313943 RefSeq - NM_001313941 RefSeq - NM_001313944 RefSeq - NM_001313945 RefSeq - NM_001313947 RefSeq - NM_001664 RefSeq Peptide - NP_001300874 RefSeq Peptide - NP_001300876 RefSeq Peptide - NP_001655 RefSeq Peptide - NP_001300870 RefSeq Peptide - NP_001300872 RefSeq Peptide - NP_001300873 swissprot - C9JX21 swissprot - C9JRM1 swissprot - P61586 swissprot - C9JNR4 swissprot - A0A024R324 Ensembl - ENSG00000067560

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rhoab	ENSDARG00000094673	Danio rerio
RHOA	ENSGALG00000003806	Gallus gallus
Rhoa	ENSMUSG00000007815	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
RHOC / P08134 / ras homolog family member C	ENSG00000155366	92
RHOB / P62745 / ras homolog family member B	ENSG00000143878	85
AL603832.3	ENSG00000271810	55
RHOD / O00212 / ras homolog family member D	ENSG00000173156	51
RND3 / P61587 / Rho family GTPase 3	ENSG00000115963	50
RND2 / P52198 / Rho family GTPase 2	ENSG00000108830	49
RHOF / Q9HBH0 / ras homolog family member F, filopodia associated	ENSG00000139725	48
RND1 / Q92730 / Rho family GTPase 1	ENSG00000172602	42

Protein motifs (from Interpro)

Interpro ID	Name
IPR001806	Small GTPase superfamily
IPR003578	Small GTPase superfamily, Rho type
IPR005225	Small GTP-binding protein domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000902	cell morphogenesis	IEA
biological_process	GO:0001666	response to hypoxia	IEA
biological_process	GO:0001998	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IEA
biological_process	GO:0002363	alpha-beta T cell lineage commitment	IEA
biological_process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0007010	cytoskeleton organization	IEA
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007160	cell-matrix adhesion	IEA
biological_process	GO:0007179	transforming growth factor beta receptor signaling pathway	TAS
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
biological_process	GO:0007264	small GTPase mediated signal transduction	IEA
biological_process	GO:0007266	Rho protein signal transduction	TAS
biological_process	GO:0007519	skeletal muscle tissue development	IEA
biological_process	GO:0008064	regulation of actin polymerization or depolymerization	IEA
biological_process	GO:0009612	response to mechanical stimulus	IEA
biological_process	GO:0009749	response to glucose	IEA
biological_process	GO:0010812	negative regulation of cell-substrate adhesion	ISS
biological_process	GO:0010975	regulation of neuron projection development	IEA
biological_process	GO:0010977	negative regulation of neuron projection development	IEA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016477	cell migration	IMP
biological_process	GO:0016579	protein deubiquitination	TAS
biological_process	GO:0021762	substantia nigra development	HEP
biological_process	GO:0021795	cerebral cortex cell migration	IEA
biological_process	GO:0021861	forebrain radial glial cell differentiation	IEA
biological_process	GO:0030036	actin cytoskeleton organization	TAS
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0030307	positive regulation of cell growth	IEA
biological_process	GO:0030334	regulation of cell migration	IMP
biological_process	GO:0030335	positive regulation of cell migration	IEA
biological_process	GO:0030521	androgen receptor signaling pathway	IEA
biological_process	GO:0030838	positive regulation of actin filament polymerization	IEA
biological_process	GO:0031098	stress-activated protein kinase signaling cascade	IEA
biological_process	GO:0031532	actin cytoskeleton reorganization	IMP
biological_process	GO:0032467	positive regulation of cytokinesis	IMP
biological_process	GO:0032956	regulation of actin cytoskeleton organization	IDA
biological_process	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	IEA
biological_process	GO:0033688	regulation of osteoblast proliferation	ISS
biological_process	GO:0034329	cell junction assembly	IMP
biological_process	GO:0035385	Roundabout signaling pathway	IDA
biological_process	GO:0036089	cleavage furrow formation	IDA
biological_process	GO:0038027	apolipoprotein A-I-mediated signaling pathway	IMP
biological_process	GO:0042476	odontogenesis	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP
biological_process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IEA
biological_process	GO:0043149	stress fiber assembly	IMP
biological_process	GO:0043200	response to amino acid	IEA
biological_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
biological_process	GO:0043297	apical junction assembly	IMP
biological_process	GO:0043312	neutrophil degranulation	TAS
biological_process	GO:0043366	beta selection	IEA
biological_process	GO:0043524	negative regulation of neuron apoptotic process	IEA
biological_process	GO:0043525	positive regulation of neuron apoptotic process	IEA
biological_process	GO:0043542	endothelial cell migration	IGI
biological_process	GO:0043931	ossification involved in bone maturation	ISS
biological_process	GO:0044319	wound healing, spreading of cells	ISS
biological_process	GO:0045198	establishment of epithelial cell apical/basal polarity	IMP
biological_process	GO:0045471	response to ethanol	IEA
biological_process	GO:0045665	negative regulation of neuron differentiation	IEA
biological_process	GO:0045666	positive regulation of neuron differentiation	IMP
biological_process	GO:0045727	positive regulation of translation	IEA
biological_process	GO:0045785	positive regulation of cell adhesion	IEA
biological_process	GO:0045792	negative regulation of cell size	IMP
biological_process	GO:0045907	positive regulation of vasoconstriction	IEA
biological_process	GO:0045987	positive regulation of smooth muscle contraction	IEA
biological_process	GO:0046039	GTP metabolic process	IEA
biological_process	GO:0046638	positive regulation of alpha-beta T cell differentiation	IEA
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	TAS
biological_process	GO:0048013	ephrin receptor signaling pathway	TAS
biological_process	GO:0048015	phosphatidylinositol-mediated signaling	TAS
biological_process	GO:0048812	neuron projection morphogenesis	IEA
biological_process	GO:0050771	negative regulation of axonogenesis	TAS
biological_process	GO:0050772	positive regulation of axonogenesis	TAS
biological_process	GO:0050773	regulation of dendrite development	IEA
biological_process	GO:0050919	negative chemotaxis	IMP
biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	TAS
biological_process	GO:0051301	cell division	IEA
biological_process	GO:0051384	response to glucocorticoid	IEA
biological_process	GO:0051496	positive regulation of stress fiber assembly	IDA
biological_process	GO:0051893	regulation of focal adhesion assembly	TAS
biological_process	GO:0051924	regulation of calcium ion transport	IEA
biological_process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	NAS
biological_process	GO:0060193	positive regulation of lipase activity	IMP
biological_process	GO:0060548	negative regulation of cell death	IEA
biological_process	GO:0061383	trabecula morphogenesis	ISS
biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	IEA
biological_process	GO:0071222	cellular response to lipopolysaccharide	IDA
biological_process	GO:0071803	positive regulation of podosome assembly	IEA
biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	IDA
biological_process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	IGI
biological_process	GO:0090307	mitotic spindle assembly	IMP
biological_process	GO:0090324	negative regulation of oxidative phosphorylation	IEA
biological_process	GO:0097498	endothelial tube lumen extension	IGI
biological_process	GO:1902766	skeletal muscle satellite cell migration	ISS
biological_process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	IEA
biological_process	GO:1903673	mitotic cleavage furrow formation	IMP
biological_process	GO:1904695	positive regulation of vascular smooth muscle contraction	IEA
biological_process	GO:1905244	regulation of modification of synaptic structure	IEA
biological_process	GO:1990869	cellular response to chemokine	IMP
biological_process	GO:2000145	regulation of cell motility	TAS
biological_process	GO:2000177	regulation of neural precursor cell proliferation	IEA
biological_process	GO:2000406	positive regulation of T cell migration	IMP
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005768	endosome	IMP
cellular_component	GO:0005789	endoplasmic reticulum membrane	TAS
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005925	focal adhesion	HDA
cellular_component	GO:0005938	cell cortex	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030027	lamellipodium	ISS
cellular_component	GO:0030054	cell junction	TAS
cellular_component	GO:0030424	axon	IEA
cellular_component	GO:0030496	midbody	IEA
cellular_component	GO:0030667	secretory granule membrane	TAS
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IDA
cellular_component	GO:0031982	vesicle	IDA
cellular_component	GO:0032154	cleavage furrow	IEA
cellular_component	GO:0032587	ruffle membrane	IEA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0043197	dendritic spine	IDA
cellular_component	GO:0043296	apical junction complex	IDA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0071944	cell periphery	IMP
cellular_component	GO:0101003	ficolin-1-rich granule membrane	TAS
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003924	GTPase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005525	GTP binding	IEA
molecular_function	GO:0017022	myosin binding	IPI
molecular_function	GO:0019003	GDP binding	IEA
molecular_function	GO:0019904	protein domain specific binding	IEA
molecular_function	GO:0051022	Rho GDP-dissociation inhibitor binding	IEA

Pathways (from Reactome)

Pathway description

GPVI-mediated activation cascade

Axonal growth inhibition (RHOA activation)

Rho GTPase cycle

PI3K/AKT activation

Axonal growth stimulation

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

G beta:gamma signalling through PI3Kgamma

EPHB-mediated forward signaling

EPHA-mediated growth cone collapse

PCP/CE pathway

G alpha (12/13) signalling events

Sema4D mediated inhibition of cell attachment and migration

Sema4D induced cell migration and growth-cone collapse

VEGFA-VEGFR2 Pathway

RHO GTPases activate PKNs

RHO GTPases activate CIT

RHO GTPases activate KTN1

RHO GTPases Activate ROCKs

RHO GTPases Activate Formins

RHO GTPases Activate Rhotekin and Rhophilins

Ovarian tumor domain proteases

ERBB2 Regulates Cell Motility

Neutrophil degranulation

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

SLIT2:ROBO1 increases RHOA activity

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000213977	O14907 / TAX1BP3 / Tax1 binding protein 3	/ reaction / complex
ENSG00000104863	LIN7B / Q9HAP6 / lin-7 homolog B, crumbs cell polarity complex component	/ complex / reaction
ENSG00000131941	RHPN2 / Q8IUC4 / rhophilin Rho GTPase binding protein 2	/ complex / reaction
ENSG00000114993	RTKN / Q9BST9 / rhotekin	/ complex / reaction
ENSG00000113070	HBEGF / Q99075 / heparin binding EGF like growth factor	/ complex / reaction
ENSG00000124882	EREG / O14944 / epiregulin	/ complex / reaction
ENSG00000131504	DIAPH1 / O60610 / diaphanous related formin 1	/ complex / reaction
ENSG00000178568	ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4	/ complex / reaction
ENSG00000122966	CIT / O14578 / citron rho-interacting serine/threonine kinase	/ reaction / complex
ENSG00000066248	NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factor	/ reaction
ENSG00000105357	MYH14 / Q7Z406 / myosin heavy chain 14	/ reaction
ENSG00000126861	OMG / P23515 / oligodendrocyte myelin glycoprotein	/ reaction / complex
ENSG00000064300	NGFR / P08138 / nerve growth factor receptor	/ complex / reaction
ENSG00000080824	P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1	/ reaction
ENSG00000134318	ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2	/ complex / reaction
ENSG00000058272	O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A	/ reaction
ENSG00000169783	LINGO1 / Q96FE5 / leucine rich repeat and Ig domain containing 1	/ reaction / complex
ENSG00000174996	KLC2 / Q9H0B6 / kinesin light chain 2	/ reaction / complex
ENSG00000112715	VEGFA / P15692 / vascular endothelial growth factor A	/ reaction
ENSG00000133026	MYH10 / P35580 / myosin heavy chain 10	/ reaction
ENSG00000123143	PKN1 / Q16512 / protein kinase N1	/ reaction / complex
ENSG00000040608	RTN4R / Q9BZR6 / reticulon 4 receptor	/ complex / reaction
ENSG00000107338	SHB / Q15464 / SH2 domain containing adaptor protein B	/ reaction
ENSG00000133392	MYH11 / P35749 / myosin heavy chain 11	/ reaction
ENSG00000067900	ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1	/ reaction / complex
ENSG00000169398	PTK2 / Q05397 / protein tyrosine kinase 2	/ reaction
ENSG00000140992	PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1	/ reaction / complex
ENSG00000155980	KIF5A / Q12840 / kinesin family member 5A	/ reaction / complex
ENSG00000101335	MYL9 / P24844 / myosin light chain 9	/ reaction
ENSG00000126214	KLC1 / Q07866 / kinesin light chain 1	/ complex / reaction
ENSG00000100592	DAAM1 / Q9Y4D1 / dishevelled associated activator of morphogenesis 1	/ complex / reaction
ENSG00000106683	LIMK1 / P53667 / LIM domain kinase 1	/ reaction
ENSG00000158106	RHPN1 / Q8TCX5 / rhophilin Rho GTPase binding protein 1	/ complex / reaction
ENSG00000196588	MKL1 / Q969V6 / megakaryoblastic leukemia (translocation) 1	/ reaction
ENSG00000075624	ACTB / P60709 / actin beta	/ reaction / complex
ENSG00000004975	DVL2 / O14641 / dishevelled segment polarity protein 2	/ complex / reaction
ENSG00000132535	DLG4 / P78352 / discs large MAGUK scaffold protein 4	/ complex / reaction
ENSG00000118193	KIF14 / Q15058 / kinesin family member 14	/ reaction / complex
ENSG00000115310	RTN4 / Q9NQC3 / reticulon 4	/ reaction / complex
ENSG00000134259	NGF / P01138 / nerve growth factor	/ reaction / complex
ENSG00000092841	MYL6 / P60660 / myosin light chain 6	/ reaction
ENSG00000141522	P52565 / ARHGDIA / Rho GDP dissociation inhibitor alpha	/ complex
ENSG00000160007	Q9NRY4 / ARHGAP35 / Rho GTPase activating protein 35	/ reaction / complex
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ reaction
ENSG00000213639	P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta	/ reaction
ENSG00000128052	KDR / P35968 / kinase insert domain receptor	/ reaction
ENSG00000077157	O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B	/ reaction
ENSG00000065371	ROPN1 / Q9HAT0 / rhophilin associated tail protein 1	/ complex / reaction
ENSG00000100345	MYH9 / P35579 / myosin heavy chain 9	/ reaction
ENSG00000105695	MAG / P20916 / myelin associated glycoprotein	/ reaction / complex
ENSG00000118680	MYL12B / O14950 / myosin light chain 12B	/ reaction
ENSG00000065243	PKN2 / Q16513 / protein kinase N2	/ reaction / complex
ENSG00000184009	ACTG1 / P63261 / actin gamma 1	/ reaction / complex
ENSG00000138798	EGF / P01133 / epidermal growth factor	/ reaction / complex
ENSG00000164050	O43157 / PLXNB1 / plexin B1	/ reaction
ENSG00000158458	NRG2 / O14511 / neuregulin 2	/ complex / reaction
ENSG00000146648	EGFR / P00533 / epidermal growth factor receptor	/ reaction / complex
ENSG00000214944	Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28	/ reaction
ENSG00000157168	NRG1 / Q02297 / neuregulin 1	/ complex / reaction
ENSG00000065361	ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3	/ complex / reaction
ENSG00000141736	ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2	/ reaction / complex
ENSG00000162959	MEMO1 / Q9Y316 / mediator of cell motility 1	/ complex / reaction
ENSG00000172602	RND1 / Q92730 / Rho family GTPase 1	/ reaction
ENSG00000126777	KTN1 / Q86UP2 / kinectin 1	/ reaction / complex
ENSG00000076928	Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1	/ reaction
ENSG00000101977	MCF2 / P10911 / MCF.2 cell line derived transforming sequence	/ reaction
ENSG00000134215	VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3	/ reaction
ENSG00000187764	Q92854 / SEMA4D / semaphorin 4D	/ reaction
ENSG00000132694	O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11	/ reaction
ENSG00000196914	Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12	/ reaction
ENSG00000198901	PRC1 / O43663 / protein regulator of cytokinesis 1	/ reaction / complex
ENSG00000160293	VAV2 / P52735 / vav guanine nucleotide exchange factor 2	/ reaction
ENSG00000196405	EVL / Q9UI08 / Enah/Vasp-like	/ reaction / complex
ENSG00000174808	BTC / P35070 / betacellulin	/ complex / reaction
ENSG00000169752	NRG4 / Q8WWG1 / neuregulin 4	/ complex / reaction
ENSG00000099331	MYO9B / Q13459 / myosin IXB	/ reaction
ENSG00000120063	GNA13 / Q14344 / G protein subunit alpha 13	/ reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr