ENSG00000067596


Homo sapiens

Features
Gene ID: ENSG00000067596
  
Biological name :DHX8
  
Synonyms : DEAH-box helicase 8 / DHX8 / Q14562
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.31
Gene start: 43483865
Gene end: 43544463
  
Corresponding Affymetrix probe sets: 203334_at (Human Genome U133 Plus 2.0 Array)   227079_at (Human Genome U133 Plus 2.0 Array)   231184_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000437886
Ensembl peptide - ENSP00000466900
Ensembl peptide - ENSP00000467834
Ensembl peptide - ENSP00000262415
Ensembl peptide - ENSP00000465178
NCBI entrez gene - 1659     See in Manteia.
OMIM - 600396
RefSeq - NM_001322218
RefSeq - NM_001302623
RefSeq - NM_001322216
RefSeq - NM_001322217
RefSeq - NM_001322219
RefSeq - NM_001322220
RefSeq - NM_001322221
RefSeq - NM_004941
RefSeq Peptide - NP_001289552
RefSeq Peptide - NP_001309146
RefSeq Peptide - NP_001309147
RefSeq Peptide - NP_001309148
RefSeq Peptide - NP_001309149
RefSeq Peptide - NP_001309145
RefSeq Peptide - NP_004932
RefSeq Peptide - NP_001309150
swissprot - F5H658
swissprot - Q14562
swissprot - K7EJH9
swissprot - K7END7
swissprot - K7EQH7
Ensembl - ENSG00000067596
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx8ENSDARG00000054707Danio rerio
 DHX8ENSGALG00000032305Gallus gallus
 Dhx8ENSMUSG00000034931Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DHX38 / Q92620 / DEAH-box helicase 38ENSG0000014082937
DHX16 / O60231 / DEAH-box helicase 16ENSG0000020456037
DHX15 / O43143 / DEAH-box helicase 15ENSG0000010960631
DHX35 / Q9H5Z1 / DEAH-box helicase 35ENSG0000010145227
DHX33 / Q9H6R0 / DEAH-box helicase 33ENSG0000000510026
DHX40 / Q8IX18 / DEAH-box helicase 40ENSG0000010840625
DHX34 / Q14147 / DExH-box helicase 34ENSG0000013481522


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR003029  S1 domain
 IPR007502  Helicase-associated domain
 IPR011709  Domain of unknown function DUF1605
 IPR012340  Nucleic acid-binding, OB-fold
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR022967  RNA-binding domain, S1
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IBA
 biological_processGO:0006396 RNA processing TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005681 spliceosomal complex TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0071007 U2-type catalytic step 2 spliceosome IDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity TAS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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