ENSG00000068912


Homo sapiens

Features
Gene ID: ENSG00000068912
  
Biological name :ERLEC1
  
Synonyms : endoplasmic reticulum lectin 1 / ERLEC1 / Q96DZ1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p16.2
Gene start: 53787044
Gene end: 53818819
  
Corresponding Affymetrix probe sets: 224628_at (Human Genome U133 Plus 2.0 Array)   224630_at (Human Genome U133 Plus 2.0 Array)   244452_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000185150
Ensembl peptide - ENSP00000367485
Ensembl peptide - ENSP00000385629
NCBI entrez gene - 27248     See in Manteia.
OMIM - 611229
RefSeq - XM_011532766
RefSeq - NM_001127397
RefSeq - NM_001127398
RefSeq - NM_015701
RefSeq Peptide - NP_001120870
RefSeq Peptide - NP_056516
RefSeq Peptide - NP_001120869
swissprot - Q96DZ1
swissprot - V9HWD3
Ensembl - ENSG00000068912
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erlec1ENSDARG00000086309Danio rerio
 ERLEC1ENSGALG00000008172Gallus gallus
 Erlec1ENSMUSG00000020311Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OS9 / Q13438 / OS9, endoplasmic reticulum lectinENSG0000013550625


Protein motifs (from Interpro)
Interpro ID Name
 IPR009011  Mannose-6-phosphate receptor binding domain superfamily
 IPR012913  Protein OS9-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IBA
 biological_processGO:0036503 ERAD pathway TAS
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:1904153 negative regulation of retrograde protein transport, ER to cytosol IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051082 unfolded protein binding IDA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
Hedgehog ligand biogenesis
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
Defective CFTR causes cystic fibrosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072849 DERL2 / Q9GZP9 / derlin 2  / reaction / complex
 ENSG00000164690 SHH / Q15465 / sonic hedgehog  / complex / reaction
 ENSG00000162298 SYVN1 / Q86TM6 / synoviolin 1  / complex / reaction
 ENSG00000165280 VCP / P55072 / valosin containing protein  / reaction / complex
 ENSG00000071537 SEL1L / Q9UBV2 / SEL1L ERAD E3 ligase adaptor subunit  / reaction / complex






 

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