ENSG00000070961


Homo sapiens

Features
Gene ID: ENSG00000070961
  
Biological name :ATP2B1
  
Synonyms : ATP2B1 / ATPase plasma membrane Ca2+ transporting 1 / P20020
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q21.33
Gene start: 89588049
Gene end: 89709300
  
Corresponding Affymetrix probe sets: 209281_s_at (Human Genome U133 Plus 2.0 Array)   212930_at (Human Genome U133 Plus 2.0 Array)   215716_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000376869
Ensembl peptide - ENSP00000392043
Ensembl peptide - ENSP00000489171
Ensembl peptide - ENSP00000447096
Ensembl peptide - ENSP00000447041
Ensembl peptide - ENSP00000261173
Ensembl peptide - ENSP00000352054
NCBI entrez gene - 490     See in Manteia.
OMIM - 108731
RefSeq - NM_001682
RefSeq - XM_017019359
RefSeq - XM_017019358
RefSeq - XM_017019357
RefSeq - XM_011538407
RefSeq - NM_001001323
RefSeq Peptide - NP_001001323
RefSeq Peptide - NP_001673
swissprot - A0A0U1RQU3
swissprot - P20020
swissprot - H0YHH6
swissprot - F8W1V5
swissprot - A0A024RBC7
swissprot - E7ERY9
Ensembl - ENSG00000070961
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2b1aENSDARG00000012684Danio rerio
 atp2b1bENSDARG00000007788Danio rerio
 ATP2B1ENSGALG00000030550Gallus gallus
 Atp2b1ENSMUSG00000019943Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP2B3 / Q16720 / ATPase plasma membrane Ca2+ transporting 3ENSG0000006784281
ATP2B2 / Q01814 / ATPase plasma membrane Ca2+ transporting 2ENSG0000015708781
ATP2B4 / P23634 / ATPase plasma membrane Ca2+ transporting 4ENSG0000005866876


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR006408  P-type ATPase, subfamily IIB
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR022141  Plasma membrane calcium transporting P-type ATPase, C-terminal
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030320  Plasma membrane calcium-transporting ATPase 1
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071386 cellular response to corticosterone stimulus IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1901660 calcium ion export IEA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 biological_processGO:1990034 calcium ion export across plasma membrane IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032591 dendritic spine membrane IEA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015085 calcium ion transmembrane transporter activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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