ENSG00000077380


Homo sapiens

Features
Gene ID: ENSG00000077380
  
Biological name :DYNC1I2
  
Synonyms : DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2 / Q13409
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q31.1
Gene start: 171687409
Gene end: 171748420
  
Corresponding Affymetrix probe sets: 211684_s_at (Human Genome U133 Plus 2.0 Array)   236698_at (Human Genome U133 Plus 2.0 Array)   242363_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386886
Ensembl peptide - ENSP00000386591
Ensembl peptide - ENSP00000388699
Ensembl peptide - ENSP00000423339
Ensembl peptide - ENSP00000415410
Ensembl peptide - ENSP00000410807
Ensembl peptide - ENSP00000409951
Ensembl peptide - ENSP00000406104
Ensembl peptide - ENSP00000405454
Ensembl peptide - ENSP00000403089
Ensembl peptide - ENSP00000401005
Ensembl peptide - ENSP00000398765
Ensembl peptide - ENSP00000397654
Ensembl peptide - ENSP00000394492
Ensembl peptide - ENSP00000392741
Ensembl peptide - ENSP00000339430
Ensembl peptide - ENSP00000380308
Ensembl peptide - ENSP00000386397
Ensembl peptide - ENSP00000386415
Ensembl peptide - ENSP00000386522
NCBI entrez gene - 1781     See in Manteia.
OMIM - 603331
RefSeq - NM_001320884
RefSeq - NM_001271785
RefSeq - NM_001271786
RefSeq - NM_001271787
RefSeq - NM_001271788
RefSeq - NM_001271789
RefSeq - NM_001271790
RefSeq - NM_001320882
RefSeq - NM_001320883
RefSeq - NM_001378
RefSeq - XM_006712347
RefSeq - XM_017003525
RefSeq Peptide - NP_001258719
RefSeq Peptide - NP_001307811
RefSeq Peptide - NP_001307812
RefSeq Peptide - NP_001307813
RefSeq Peptide - NP_001369
RefSeq Peptide - NP_001258716
RefSeq Peptide - NP_001258717
RefSeq Peptide - NP_001258714
RefSeq Peptide - NP_001258715
RefSeq Peptide - NP_001258718
swissprot - E7ERR6
swissprot - E7ERH4
swissprot - E7EQU2
swissprot - E7EMU4
swissprot - E7EQL5
swissprot - A0A140VKE9
swissprot - Q13409
swissprot - E9PGG1
swissprot - E7EV09
swissprot - E7EUM4
swissprot - E7EU01
swissprot - E7ETL8
swissprot - E7ET01
swissprot - E7ESD3
Ensembl - ENSG00000077380
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dync1i2aENSDARG00000078386Danio rerio
 dync1i2bENSDARG00000103195Danio rerio
 DYNC1I2ENSGALG00000009551Gallus gallus
 O88487ENSMUSG00000027012Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1ENSG0000015856076
WDR78 / Q5VTH9 / WD repeat domain 78ENSG0000015276322
DNAI1 / Q9UI46 / dynein axonemal intermediate chain 1ENSG0000012273519
DNAI2 / Q9GZS0 / dynein axonemal intermediate chain 2ENSG0000017159516
WDR34 / Q96EX3 / WD repeat domain 34ENSG0000011933315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR025956  Cytoplasmic dynein 1 intermediate chain 1/2
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0010970 transport along microtubule IBA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:2000582 positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005868 cytoplasmic dynein complex IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0031982 vesicle IDA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0045503 dynein light chain binding IBA
 molecular_functionGO:0045504 dynein heavy chain binding IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex
 ENSG00000135720 O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2  / complex
 ENSG00000144635 Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1  / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / complex
 ENSG00000151746 BICD1 / Q96G01 / BICD cargo adaptor 1  / complex / reaction
 ENSG00000177938 CAPZA3 / Q96KX2 / capping actin protein of muscle Z-line alpha subunit 3  / complex
 ENSG00000077380 Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2  / complex
 ENSG00000116489 CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1  / complex
 ENSG00000143641 GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2  / reaction / complex
 ENSG00000138107 ACTR1A / P61163 / ARP1 actin related protein 1 homolog A  / complex
 ENSG00000158560 O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1  / complex
 ENSG00000141429 GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1  / reaction / complex
 ENSG00000077549 CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit  / complex
 ENSG00000166847 DCTN5 / Q9BTE1 / dynactin subunit 5  / complex
 ENSG00000104671 DCTN6 / O00399 / dynactin subunit 6  / complex
 ENSG00000137100 DCTN3 / O75935 / dynactin subunit 3  / complex
 ENSG00000131966 ACTR10 / Q9NZ32 / actin related protein 10 homolog  / complex
 ENSG00000175203 DCTN2 / Q13561 / dynactin subunit 2  / complex
 ENSG00000132912 DCTN4 / Q9UJW0 / dynactin subunit 4  / complex
 ENSG00000198898 CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2  / complex
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / reaction / complex
 ENSG00000197102 Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1  / complex
 ENSG00000204843 DCTN1 / Q14203 / dynactin subunit 1  / complex
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex






 

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