ENSG00000083312


Homo sapiens

Features
Gene ID: ENSG00000083312
  
Biological name :TNPO1
  
Synonyms : Q92973 / TNPO1 / transportin 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.2
Gene start: 72816312
Gene end: 72916733
  
Corresponding Affymetrix probe sets: 1556116_s_at (Human Genome U133 Plus 2.0 Array)   1557278_s_at (Human Genome U133 Plus 2.0 Array)   207657_x_at (Human Genome U133 Plus 2.0 Array)   209225_x_at (Human Genome U133 Plus 2.0 Array)   209226_s_at (Human Genome U133 Plus 2.0 Array)   212635_at (Human Genome U133 Plus 2.0 Array)   221829_s_at (Human Genome U133 Plus 2.0 Array)   225765_at (Human Genome U133 Plus 2.0 Array)   225766_s_at (Human Genome U133 Plus 2.0 Array)   243324_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474059
Ensembl peptide - ENSP00000425118
Ensembl peptide - ENSP00000428899
Ensembl peptide - ENSP00000430312
Ensembl peptide - ENSP00000336712
NCBI entrez gene - 3842     See in Manteia.
OMIM - 602901
RefSeq - XM_017009458
RefSeq - NM_002270
RefSeq - NM_153188
RefSeq - XM_005248500
RefSeq - XM_005248501
RefSeq Peptide - NP_694858
RefSeq Peptide - NP_002261
swissprot - Q92973
swissprot - E7EW37
swissprot - S4R398
swissprot - A0A024RAM0
Ensembl - ENSG00000083312
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnpo1ENSDARG00000035390Danio rerio
 TNPO1ENSGALG00000015014Gallus gallus
 Tnpo1ENSMUSG00000009470Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNPO2 / O14787 / transportin 2ENSG0000010557685


Protein motifs (from Interpro)
Interpro ID Name
 IPR001494  Importin-beta, N-terminal domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation TAS
 biological_processGO:0006607 NLS-bearing protein import into nucleus IBA
 biological_processGO:0006610 ribosomal protein import into nucleus IBA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0035735 intraciliary transport involved in cilium assembly TAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005929 cilium TAS
 cellular_componentGO:0031965 nuclear membrane IBA
 cellular_componentGO:0034399 nuclear periphery IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008139 nuclear localization sequence binding TAS
 molecular_functionGO:0008536 Ran GTPase binding IEA
 molecular_functionGO:0008565 protein transporter activity IBA


Pathways (from Reactome)
Pathway description
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117245 KIF17 / Q9P2E2 / kinesin family member 17  / complex / reaction
 ENSG00000162889 P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction / complex






 

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