ENSG00000088832


Homo sapiens

Features
Gene ID: ENSG00000088832
  
Biological name :FKBP1A
  
Synonyms : FK506 binding protein 1A / FKBP1A / P62942
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: p13
Gene start: 1368978
Gene end: 1393172
  
Corresponding Affymetrix probe sets: 200709_at (Human Genome U133 Plus 2.0 Array)   210186_s_at (Human Genome U133 Plus 2.0 Array)   210187_at (Human Genome U133 Plus 2.0 Array)   214119_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409863
Ensembl peptide - ENSP00000478093
Ensembl peptide - ENSP00000482758
Ensembl peptide - ENSP00000480846
Ensembl peptide - ENSP00000371134
Ensembl peptide - ENSP00000371138
Ensembl peptide - ENSP00000371143
Ensembl peptide - ENSP00000383003
NCBI entrez gene - 2280     See in Manteia.
OMIM - 186945
RefSeq - NM_000801
RefSeq - NM_001199786
RefSeq - NM_054014
RefSeq Peptide - NP_001186715
RefSeq Peptide - NP_463460
RefSeq Peptide - NP_000792
swissprot - Q5W0X3
swissprot - A0A087WTS4
swissprot - P62942
swissprot - Q1JUQ3
swissprot - Q1JUQ5
swissprot - A0A087WZM5
Ensembl - ENSG00000088832
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FKBP1CENSGALG00000027151Gallus gallus
 Fkbp1aENSMUSG00000032966Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FKBP1C / FK506 binding protein 1CENSG0000019822595
FKBP1B / P68106 / FK506 binding protein 1BENSG0000011978283
FKBP4 / Q02790 / FK506 binding protein 4ENSG0000000447851
FKBP3 / Q00688 / FK506 binding protein 3ENSG0000010044248
FKBP5 / Q13451 / FK506 binding protein 5ENSG0000009606048


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0003007 heart morphogenesis ISS
 biological_processGO:0006457 protein folding NAS
 biological_processGO:0006458 "de novo" protein folding TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007183 SMAD protein complex assembly IDA
 biological_processGO:0022417 protein maturation by protein folding TAS
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0032880 regulation of protein localization IGI
 biological_processGO:0032925 regulation of activin receptor signaling pathway IDA
 biological_processGO:0042026 protein refolding TAS
 biological_processGO:0042110 T cell activation NAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis ISS
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity ISS
 biological_processGO:0060347 heart trabecula formation ISS
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 biological_processGO:0070588 calcium ion transmembrane transport NAS
 biological_processGO:0097435 supramolecular fiber organization IDA
 biological_processGO:1902991 regulation of amyloid precursor protein catabolic process IGI
 biological_processGO:1990000 amyloid fibril formation IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0014802 terminal cisterna ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum ISS
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0031312 extrinsic component of organelle membrane ISS
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098562 cytoplasmic side of membrane ISS
 cellular_componentGO:1990425 ryanodine receptor complex ISS
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005160 transforming growth factor beta receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005527 macrolide binding NAS
 molecular_functionGO:0005528 FK506 binding NAS
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding ISS
 molecular_functionGO:0044325 ion channel binding TAS
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0048185 activin binding IPI


Pathways (from Reactome)
Pathway description
Calcineurin activates NFAT
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / reaction
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / reaction
 ENSG00000106799 P36897 / TGFBR1 / transforming growth factor beta receptor 1  / reaction / complex
 ENSG00000088832 FKBP1A / P62942 / FK506 binding protein 1A  / complex / reaction






 

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