ENSG00000090447


Homo sapiens

Features
Gene ID: ENSG00000090447
  
Biological name :TFAP4
  
Synonyms : Q01664 / TFAP4 / transcription factor AP-4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.3
Gene start: 4257186
Gene end: 4273075
  
Corresponding Affymetrix probe sets: 205688_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000204517
Ensembl peptide - ENSP00000459390
Ensembl peptide - ENSP00000460067
Ensembl peptide - ENSP00000461352
NCBI entrez gene - 7023     See in Manteia.
OMIM - 600743
RefSeq - XM_011522635
RefSeq - NM_003223
RefSeq - XM_011522633
RefSeq Peptide - NP_003214
swissprot - I3L254
swissprot - Q01664
swissprot - I3L301
swissprot - I3L4L6
Ensembl - ENSG00000090447
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfap4ENSDARG00000103923Danio rerio
 TFAP4ENSGALG00000027823Gallus gallus
 Tfap4ENSMUSG00000005718Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0043922 negative regulation by host of viral transcription NAS
 biological_processGO:0043923 positive regulation by host of viral transcription IDA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IMP
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:1901990 regulation of mitotic cell cycle phase transition IDA
 biological_processGO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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