ENSG00000091879


Homo sapiens

Features
Gene ID: ENSG00000091879
  
Biological name :ANGPT2
  
Synonyms : angiopoietin 2 / ANGPT2 / O15123
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p23.1
Gene start: 6499651
Gene end: 6563409
  
Corresponding Affymetrix probe sets: 205572_at (Human Genome U133 Plus 2.0 Array)   211148_s_at (Human Genome U133 Plus 2.0 Array)   236034_at (Human Genome U133 Plus 2.0 Array)   237261_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486858
Ensembl peptide - ENSP00000314897
Ensembl peptide - ENSP00000343517
Ensembl peptide - ENSP00000428023
NCBI entrez gene - 285     See in Manteia.
OMIM - 601922
RefSeq - XM_017013318
RefSeq - NM_001118887
RefSeq - NM_001118888
RefSeq - NM_001147
RefSeq Peptide - NP_001112359
RefSeq Peptide - NP_001112360
RefSeq Peptide - NP_001138
swissprot - O15123
swissprot - E7EVQ3
Ensembl - ENSG00000091879
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angpt2aENSDARG00000014946Danio rerio
 ANGPT2ENSGALG00000036189Gallus gallus
 Angpt2ENSMUSG00000031465Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANGPT1 / Q15389 / angiopoietin 1ENSG0000015418860
ANGPT4 / Q9Y264 / angiopoietin 4ENSG0000010128044
O95841 / ANGPTL1 / angiopoietin like 1ENSG0000011619427
Q9UKU9 / ANGPTL2 / angiopoietin like 2ENSG0000013685926
FGL2 / Q14314 / fibrinogen like 2ENSG0000012795125
O43827 / ANGPTL7 / angiopoietin like 7ENSG0000017181924
Q8NI99 / ANGPTL6 / angiopoietin like 6ENSG0000013081224
FIBCD1 / Q8N539 / fibrinogen C domain containing 1ENSG0000013072020
FCN2 / Q15485 / ficolin 2ENSG0000016033919
FCN1 / O00602 / ficolin 1ENSG0000008526519
MFAP4 / P55083 / microfibril associated protein 4ENSG0000016648218
FCN3 / O75636 / ficolin 3ENSG0000014274818


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR028844  Angiopoietin-2
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048014 Tie signaling pathway IDA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050928 negative regulation of positive chemotaxis IDA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0072012 glomerulus vasculature development ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Tie2 Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120156 TEK / Q02763 / TEK receptor tyrosine kinase  / reaction / complex






 

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