ENSG00000096060


Homo sapiens

Features
Gene ID: ENSG00000096060
  
Biological name :FKBP5
  
Synonyms : FK506 binding protein 5 / FKBP5 / Q13451
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.31
Gene start: 35573585
Gene end: 35728583
  
Corresponding Affymetrix probe sets: 204560_at (Human Genome U133 Plus 2.0 Array)   224840_at (Human Genome U133 Plus 2.0 Array)   224856_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000349811
Ensembl peptide - ENSP00000441205
Ensembl peptide - ENSP00000442340
Ensembl peptide - ENSP00000444810
NCBI entrez gene - 2289     See in Manteia.
OMIM - 602623
RefSeq - NM_001145776
RefSeq - NM_001145775
RefSeq - NM_001145777
RefSeq - NM_004117
RefSeq Peptide - NP_001139247
RefSeq Peptide - NP_001139248
RefSeq Peptide - NP_001139249
RefSeq Peptide - NP_004108
swissprot - Q13451
Ensembl - ENSG00000096060
  
Related genetic diseases (OMIM): 608516 - {Major depressive disorder and accelerated response to antidepressant drug treatment}, 608516
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fkbp5ENSDARG00000028396Danio rerio
 FKBP5ENSGALG00000042148Gallus gallus
 Fkbp5ENSMUSG00000024222Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FKBP4 / Q02790 / FK506 binding protein 4ENSG0000000447854
FKBP1A / P62942 / FK506 binding protein 1AENSG0000008883211
FKBP1B / P68106 / FK506 binding protein 1BENSG0000011978211
FKBP3 / Q00688 / FK506 binding protein 3ENSG0000010044211
FKBP1C / FK506 binding protein 1CENSG0000019822511


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type
 IPR031210  Peptidyl-prolyl cis-trans isomerase FKBP5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0061077 chaperone-mediated protein folding IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005528 FK506 binding TAS
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0031072 heat shock protein binding IPI


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
ESR-mediated signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / complex / reaction
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / reaction / complex
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / reaction / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex / reaction
 ENSG00000004478 FKBP4 / Q02790 / FK506 binding protein 4  / reaction
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / complex / reaction
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / complex / reaction






 

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