ENSG00000099284


Homo sapiens

Features
Gene ID: ENSG00000099284
  
Biological name :H2AFY2
  
Synonyms : H2AFY2 / H2A histone family member Y2 / Q9P0M6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q22.1
Gene start: 70052796
Gene end: 70112280
  
Corresponding Affymetrix probe sets: 218445_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362352
Ensembl peptide - ENSP00000404584
NCBI entrez gene - 55506     See in Manteia.
OMIM - 616141
RefSeq - NM_018649
RefSeq Peptide - NP_061119
swissprot - A0A024QZP6
swissprot - Q5SQT3
swissprot - Q9P0M6
Ensembl - ENSG00000099284
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 h2afy2ENSDARG00000087897Danio rerio
 H2AFY2ENSGALG00000004794Gallus gallus
 H2afy2ENSMUSG00000020086Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2AFY / O75367 / H2A histone family member YENSG0000011364868
Q93077 / HIST1H2AC / histone cluster 1 H2A family member cENSG0000018057323
Q6FI13 / HIST2H2AA3 / histone cluster 2 H2A family member a3ENSG0000020381223
H2AFX / P16104 / H2A histone family member XENSG0000018848623
AL031777.3ENSG0000028298823
Q6FI13 / HIST2H2AA4 / histone cluster 2 H2A family member a4ENSG0000027219623
Q7L7L0 / HIST3H2A / histone cluster 3 H2AENSG0000018121823
Q8IUE6 / HIST2H2AB / histone cluster 2 H2A family member bENSG0000018427022
P20671 / HIST1H2AD / histone cluster 1 H2A family member dENSG0000019686622
P0C0S8 / HIST1H2AL / histone cluster 1 H2A family member lENSG0000027690322
H2AFJ / Q9BTM1 / H2A histone family member JENSG0000024670522
Q96QV6 / HIST1H2AA / histone cluster 1 H2A family member aENSG0000016450822
P0C0S8 / HIST1H2AI / histone cluster 1 H2A family member iENSG0000019674722
P0C0S8 / HIST1H2AK / histone cluster 1 H2A family member kENSG0000027522122
P0C0S8 / HIST1H2AM / histone cluster 1 H2A family member mENSG0000027867722
Q96KK5 / HIST1H2AH / histone cluster 1 H2A family member hENSG0000027499722
Q16777 / HIST2H2AC / histone cluster 2 H2A family member cENSG0000018426022
Q99878 / HIST1H2AJ / histone cluster 1 H2A family member jENSG0000027636822
P0C0S8 / HIST1H2AG / histone cluster 1 H2A family member gENSG0000019678722
H2AFB1 / P0C5Y9 / H2A histone family member B1ENSG0000027418312


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR002589  Macro domain
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR021171  Core histone macro-H2A
 IPR032454  Histone H2A, C-terminal domain
 IPR035796  Core histone macro-H2A, macro domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007549 dosage compensation IDA
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IMP
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IMP
 biological_processGO:0071169 establishment of protein localization to chromatin IMP
 biological_processGO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I IGI
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0001740 Barr body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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