ENSG00000100030


Homo sapiens

Features
Gene ID: ENSG00000100030
  
Biological name :MAPK1
  
Synonyms : MAPK1 / mitogen-activated protein kinase 1 / P28482
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q11.22
Gene start: 21754500
Gene end: 21867680
  
Corresponding Affymetrix probe sets: 1552263_at (Human Genome U133 Plus 2.0 Array)   1552264_a_at (Human Genome U133 Plus 2.0 Array)   208351_s_at (Human Genome U133 Plus 2.0 Array)   212271_at (Human Genome U133 Plus 2.0 Array)   224620_at (Human Genome U133 Plus 2.0 Array)   224621_at (Human Genome U133 Plus 2.0 Array)   229847_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000215832
Ensembl peptide - ENSP00000381803
Ensembl peptide - ENSP00000440842
NCBI entrez gene - 5594     See in Manteia.
OMIM - 176948
RefSeq - NM_002745
RefSeq - NM_138957
RefSeq Peptide - NP_002736
RefSeq Peptide - NP_620407
swissprot - P28482
swissprot - Q1HBJ4
Ensembl - ENSG00000100030
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk1ENSDARG00000027552Danio rerio
 MAPK1ENSGALG00000001501Gallus gallus
 Mapk1ENSMUSG00000063358Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK3 / P27361 / mitogen-activated protein kinase 3ENSG0000010288286
MAPK7 / Q13164 / mitogen-activated protein kinase 7ENSG0000016648450
MAPK6 / Q16659 / mitogen-activated protein kinase 6ENSG0000006995642
NLK / Q9UBE8 / nemo like kinaseENSG0000008709541
MAPK4 / P31152 / mitogen-activated protein kinase 4ENSG0000014163939
MAPK15 / Q8TD08 / mitogen-activated protein kinase 15ENSG0000018108539


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008349  Mitogen-activated protein (MAP) kinase, ERK1/2
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007611 learning or memory NAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0014032 neural crest cell development IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0015966 diadenosine tetraphosphate biosynthetic process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISS
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019858 cytosine metabolic process IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030641 regulation of cellular pH IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0031647 regulation of protein stability ISS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032872 regulation of stress-activated MAPK cascade TAS
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IDA
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0035094 response to nicotine ISS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0038127 ERBB signaling pathway IDA
 biological_processGO:0042473 outer ear morphogenesis IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0051403 stress-activated MAPK cascade IDA
 biological_processGO:0051493 regulation of cytoskeleton organization TAS
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0060020 Bergmann glial cell differentiation IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060440 trachea formation IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0061308 cardiac neural crest cell development involved in heart development IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade TAS
 biological_processGO:0070849 response to epidermal growth factor IDA
 biological_processGO:0071276 cellular response to cadmium ion IMP
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0072584 caveolin-mediated endocytosis TAS
 biological_processGO:0090170 regulation of Golgi inheritance TAS
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1903351 cellular response to dopamine IMP
 biological_processGO:1904355 positive regulation of telomere capping IMP
 biological_processGO:2000641 regulation of early endosome to late endosome transport TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005770 late endosome TAS
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005901 caveola TAS
 cellular_componentGO:0005925 focal adhesion TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072686 mitotic spindle ISS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004707 MAP kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity ISS
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IPI
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
phospho-PLA2 pathway
RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Spry regulation of FGF signaling
Golgi Cisternae Pericentriolar Stack Reorganization
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000010 Recurrent urinary tract infections "Repeated infections of the urinary tract." [HPO:curators]
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 HP:0000023 Inguinal hernia 
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 HP:0000160 Microstomia "The presence of an abnormally small `mouth` (FMA:49184)." [HPO:curators]
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 HP:0000175 Cleft palate "Cleft palate is a developmental defect of the `palate` (FMA:54549) resulting from a failure of fusion of the palatine processes." [HPO:curators]
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 HP:0000219 Thin upper lip 
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 HP:0000252 Microcephaly "Microcephaly is a neurodevelopmental disorder in which the circumference of the head is more than two standard deviations smaller than the age- and gender-dependent norm." [HPO:curators]
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 HP:0000272 Malar hypoplasia "Underdeveloped midface region." [HPO:curators]
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 HP:0000276 Long face 
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 HP:0000307 Pointed chin 
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 HP:0000319 Flat philtrum 
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 HP:0000324 Facial asymmetry 
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 HP:0000363 Abnormality of ear lobes 
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 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
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 HP:0000426 Prominent nasal bridge 
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 HP:0000430 Hypoplastic nasal alae "Thinned, deficient, or excessively arched `ala nasi` (FMA:59519)." [pmid:19152422]
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 HP:0000453 Choanal atresia "Absence or abnormal closure of the choana (the posterior nasal aperture)." [HPO:curators]
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 HP:0000490 Deep set eyes 
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 HP:0000581 Blepharophimosis "Reduced width of the palpebral fissures." [HPO:sdoelken]
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 HP:0000657 Oculomotor apraxia 
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 HP:0000716 Depression "A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure." [HPO:curators]
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 HP:0000722 Obsessive-compulsive disorder 
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 HP:0001166 Arachnodactyly "Abnormally long and slender fingers ("spider fingers")." [HPO:curators]
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 HP:0001249 Mental retardation 
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 HP:0001250 Seizures "Seizures are an intermittent `abnormality of the central nervous system` (FMA:HP:0002011) due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements." [HPO:probinson]
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 HP:0001263 Developmental retardation "A delay in the achievement of motor or mental milestones manifested prior to age 18 and generally associated with lifelong mental and/or physical impairments." [HPO:curators]
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 HP:0001511 Intrauterine growth retardation 
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 HP:0001622 Premature birth 
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 HP:0001629 Ventricular septal defect "A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum." [HPO:curators]
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 HP:0001631 Atrial septal defect "Atrial septal defect (ASD) is a congenital heart defect that enables blood flow between the left and right atria via the interatrial septum. The three common types of ASD are sinus venosus defects, ostium secundum defects, and ostium primum defects." [HPO:curators]
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 HP:0001659 Aortic insufficiency "An insufficiency of the aortic valve, leading to regurgitation (backward flow) of blood from the aorta into the left ventricle." [HPO:curators]
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 HP:0001660 Persistant truncus arteriosus "Persistent Truncus Arteriosus results from a failure of the truncus arteriosus to close." [HPO:curators]
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 HP:0001763 Pes planus "A condition in which the arch of the foot is flat, with the entire sole of the foot being in near-complete contact with the ground." [HPO:curators]
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 HP:0001770 Toe syndactyly "Webbing or fusion of the toes, involving soft parts only or including bone structure. Bony fusions are revered to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the toes in a proximo-distal axis are refered to as "Symphalangism"." [HPO:curators]
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 HP:0001802 Absent toenails 
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 HP:0001817 Absent fingernails 
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 HP:0001852 Gap between first and second toes "The presence of a larger than normal gap between the first and second toes related to medial displacement of the first toe." [HPO:curators]
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 HP:0002021 Pyloric stenosis 
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 HP:0002205 Recurrent respiratory infections 
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 HP:0002463 Language impairment 
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 HP:0002553 Arched eyebrows 
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 HP:0002607 Bowel incontinence 
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 HP:0002664 Neoplasia "An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant tumour or neoplasm." [HPO:curators]
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 HP:0002673 Coxa valga "Coxa valga is a deformity of the hip in which the angle between the femoral shaft and the femoral neck is increased compared to age-adjusted values (about 150 degrees in newborns gradually reducing to 120-130 degrees in adults)." [HPO:curators]
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 HP:0002705 High, narrow palate "The presence of a high and narrow palate." [HPO:curators]
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 HP:0002721 Immunodeficiency 
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 HP:0003307 Hyperlordosis 
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 HP:0004209 Clinodactyly of the 5th finger "Clinodactyly refers to a bending or curvature of the `fifth finger` (FMA:24949) in the radial direction (i.e., towards the 4th finger)." [HPO:curators]
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 HP:0004279 Hypoplastic hand 
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 HP:0004322 Decreased body height "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." [HPO:curators]
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 HP:0004942 Aortic aneurysms 
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 HP:0005692 Joint hyperflexibility 
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 HP:0006487 Bowing of the long bones 
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 HP:0007018 Attention deficit hyperactivity disorder "Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient." [HPO:curators]
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 HP:0009465 Ulnar deviation of fingers 
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 HP:0009795 Branchial fistula "A congenital fistula in the neck resulting from incomplete closure of a branchial cleft." [HPO:curators]
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 HP:0009882 Hypoplasia of the distal phalanges of the hand 
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 HP:0010296 Ankyloglossia "Short or anteriorly attached lingual frenulum associated with limited mobility of the tongue." [pmid:19125428]
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 HP:0100033 Tic disorders "A tic is a sudden, repetitive, nonrhythmic, stereotyped motor movement or vocalization involving discrete muscle groups." [HPO:sdoelken]
Show

 HP:0100490 Camptodactyly (hands) "Contractures of one ore more joints of the fingers." [HPO:sdoelken]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078304 Q13362 / PPP2R5C / protein phosphatase 2 regulatory subunit Bgamma  / complex / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction / complex
 ENSG00000072133 Q9UK32 / RPS6KA6 / ribosomal protein S6 kinase A6  / reaction
 ENSG00000137486 ARRB1 / P49407 / arrestin beta 1  / complex / reaction
 ENSG00000134962 KLB / Q86Z14 / klotho beta  / reaction
 ENSG00000126934 MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2  / reaction / complex
 ENSG00000133116 KL / klotho / Q9UEF7  / reaction
 ENSG00000116586 Q9Y2Q5 / LAMTOR2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2  / reaction / complex
 ENSG00000141068 KSR1 / Q8IVT5 / kinase suppressor of ras 1  / reaction / complex
 ENSG00000175866 BAIAP2 / Q9UQB8 / BAI1 associated protein 2  / reaction
 ENSG00000160867 FGFR4 / P22455 / fibroblast growth factor receptor 4  / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / complex / reaction
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / reaction / complex
 ENSG00000105722 ERF / P50548 / ETS2 repressor factor  / reaction
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / reaction
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / reaction / complex
 ENSG00000100784 O75582 / RPS6KA5 / ribosomal protein S6 kinase A5  / reaction
 ENSG00000068971 Q15173 / PPP2R5B / protein phosphatase 2 regulatory subunit Bbeta  / complex / reaction
 ENSG00000162344 FGF19 / O95750 / fibroblast growth factor 19  / reaction
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / reaction
 ENSG00000170345 FOS / P01100 / Fos proto-oncogene, AP-1 transcription factor subunit  / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex / reaction
 ENSG00000172216 CEBPB / P17676 / CCAAT/enhancer binding protein beta  / reaction
 ENSG00000144730 IL17RD / Q8NFM7 / interleukin 17 receptor D  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction / complex
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / reaction / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000109270 Q9UHA4 / LAMTOR3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3  / complex / reaction
 ENSG00000123154 WDR83 / Q9BRX9 / WD repeat domain 83  / complex / reaction
 ENSG00000075413 MARK3 / P27448 / microtubule affinity regulating kinase 3  / complex / reaction
 ENSG00000068078 FGFR3 / P22607 / fibroblast growth factor receptor 3  / reaction
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex / reaction
 ENSG00000126767 ELK1 / P19419 / ELK1, ETS transcription factor  / reaction
 ENSG00000116711 P47712 / PLA2G4A / phospholipase A2 group IVA  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / reaction / complex
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction / complex
 ENSG00000169032 MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1  / complex / reaction
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / reaction
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / reaction / complex
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction
 ENSG00000117676 Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1  / reaction
 ENSG00000177189 P51812 / RPS6KA3 / ribosomal protein S6 kinase A3  / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000134954 ETS1 / P14921 / ETS proto-oncogene 1, transcription factor  / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction / complex
 ENSG00000071242 Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2  / reaction
 ENSG00000157557 ETS2 / P15036 / ETS proto-oncogene 2, transcription factor  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction / complex
 ENSG00000118972 FGF23 / Q9GZV9 / fibroblast growth factor 23  / reaction
 ENSG00000204305 AGER / Q15109 / advanced glycosylation end-product specific receptor  / reaction / complex
 ENSG00000166225 FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2  / reaction
 ENSG00000108861 DUSP3 / P51452 / dual specificity phosphatase 3  / reaction
 ENSG00000120875 DUSP4 / Q13115 / dual specificity phosphatase 4  / reaction
 ENSG00000112640 Q14738 / PPP2R5D / protein phosphatase 2 regulatory subunit Bdelta  / reaction
 ENSG00000137331 IER3 / P46695 / immediate early response 3  / reaction / complex
 ENSG00000139318 DUSP6 / Q16828 / dual specificity phosphatase 6  / reaction
 ENSG00000130829 DUSP9 / Q99956 / dual specificity phosphatase 9  / reaction
 ENSG00000162734 PEA15 / Q15121 / proliferation and apoptosis adaptor protein 15  / complex / reaction
 ENSG00000138166 DUSP5 / Q16690 / dual specificity phosphatase 5  / reaction
 ENSG00000164086 DUSP7 / Q16829 / dual specificity phosphatase 7  / reaction






 

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