ENSG00000100811


Homo sapiens

Features
Gene ID: ENSG00000100811
  
Biological name :YY1
  
Synonyms : P25490 / YY1 / YY1 transcription factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.2
Gene start: 100238298
Gene end: 100282792
  
Corresponding Affymetrix probe sets: 200047_s_at (Human Genome U133 Plus 2.0 Array)   201901_s_at (Human Genome U133 Plus 2.0 Array)   201902_s_at (Human Genome U133 Plus 2.0 Array)   213494_s_at (Human Genome U133 Plus 2.0 Array)   224711_at (Human Genome U133 Plus 2.0 Array)   224718_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262238
Ensembl peptide - ENSP00000452140
Ensembl peptide - ENSP00000452225
Ensembl peptide - ENSP00000451329
NCBI entrez gene - 7528     See in Manteia.
OMIM - 600013
RefSeq - NM_003403
RefSeq Peptide - NP_003394
swissprot - P25490
swissprot - G3V3M8
swissprot - H0YJU4
swissprot - H0YJV7
Ensembl - ENSG00000100811
  
Related genetic diseases (OMIM): 617557 - Gabriele-de Vries syndrome, 617557

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 yy1aENSDARG00000042796Danio rerio
 yy1bENSDARG00000027978Danio rerio
 YY2ENSGALG00000017388Gallus gallus
 Yy1ENSMUSG00000021264Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YY2 / O15391 / YY2 transcription factorENSG0000023079753
ZFP42 / Q96MM3 / ZFP42 zinc finger proteinENSG0000017905936
P52747 / ZNF143 / zinc finger protein 143ENSG0000016647818
ZXDB / P98169 / zinc finger, X-linked, duplicated BENSG0000019845517
MTF1 / Q14872 / metal regulatory transcription factor 1ENSG0000018878617
ZXDA / P98168 / zinc finger, X-linked, duplicated AENSG0000019820517
ZNF76 / P36508 / zinc finger protein 76ENSG0000006502916
ZXDC / Q2QGD7 / ZXD family zinc finger CENSG0000007047615
Q86VK4 / ZNF410 / zinc finger protein 410ENSG0000011972514
GTF3A / Q92664 / general transcription factor IIIAENSG0000012203414


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR017114  C2H2-type Zinc finger protein, YY-1-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006403 RNA localization IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010225 response to UV-C IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032688 negative regulation of interferon-beta production IDA
 biological_processGO:0034644 cellular response to UV IMP
 biological_processGO:0034696 response to prostaglandin F IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0051276 chromosome organization IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0031011 Ino80 complex IDA
 cellular_componentGO:0031519 PcG protein complex IEA
 molecular_functionGO:0000400 four-way junction DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046332 SMAD binding IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis
UCH proteinases
DNA Damage Recognition in GG-NER
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129514 FOXA1 / P55317 / forkhead box A1  / reaction
 ENSG00000172534 HCFC1 / P51610 / host cell factor C1  / complex
 ENSG00000141568 FOXK2 / Q01167 / forkhead box K2  / complex
 ENSG00000163930 BAP1 / Q92560 / BRCA1 associated protein 1  / complex / reaction
 ENSG00000164916 FOXK1 / P85037 / forkhead box K1  / complex
 ENSG00000143970 ASXL2 / Q76L83 / additional sex combs like 2, transcriptional regulator  / complex
 ENSG00000147162 OGT / O15294 / O-linked N-acetylglucosamine (GlcNAc) transferase  / complex
 ENSG00000137203 P05549 / TFAP2A / transcription factor AP-2 alpha  / reaction / complex
 ENSG00000171456 ASXL1 / Q8IXJ9 / additional sex combs like 1, transcriptional regulator  / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex
 ENSG00000107485 GATA3 / P23771 / GATA binding protein 3  / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex






 

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