ENSG00000101558


Homo sapiens

Features
Gene ID: ENSG00000101558
  
Biological name :VAPA
  
Synonyms : Q9P0L0 / VAMP associated protein A / VAPA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.22
Gene start: 9914002
Gene end: 9960021
  
Corresponding Affymetrix probe sets: 208780_x_at (Human Genome U133 Plus 2.0 Array)   225198_at (Human Genome U133 Plus 2.0 Array)   228480_at (Human Genome U133 Plus 2.0 Array)   239750_x_at (Human Genome U133 Plus 2.0 Array)   242780_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345656
Ensembl peptide - ENSP00000382880
Ensembl peptide - ENSP00000463155
NCBI entrez gene - 9218     See in Manteia.
OMIM - 605703
RefSeq - XM_017026079
RefSeq - NM_003574
RefSeq - NM_194434
RefSeq - XM_011525769
RefSeq Peptide - NP_919415
RefSeq Peptide - NP_003565
swissprot - Q9P0L0
swissprot - J3QKM9
Ensembl - ENSG00000101558
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top1mtENSDARG00000027824Danio rerio
 vapalENSDARG00000115862Danio rerio
 VapaENSMUSG00000024091Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VAPB / O95292 / VAMP associated protein B and CENSG0000012416451


Protein motifs (from Interpro)
Interpro ID Name
 IPR000535  Major sperm protein (MSP) domain
 IPR008962  PapD-like superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016763  Vesicle-associated membrane-protein-associated protein
 IPR030229  Vesicle-associated membrane protein-associated protein A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008219 cell death IMP
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044791 positive regulation by host of viral release from host cell IDA
 biological_processGO:0044828 negative regulation by host of viral genome replication IDA
 biological_processGO:0044829 positive regulation by host of viral genome replication IDA
 biological_processGO:0061025 membrane fusion TAS
 biological_processGO:0070972 protein localization to endoplasmic reticulum IMP
 biological_processGO:0090114 COPII-coated vesicle budding IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IMP
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0033149 FFAT motif binding IMP
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113163 Q9Y5P4 / COL4A3BP / collagen type IV alpha 3 binding protein  / reaction / complex
 ENSG00000163590 PPM1L / Q5SGD2 / protein phosphatase, Mg2+/Mn2+ dependent 1L  / complex






 

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