ENSG00000102606


Homo sapiens

Features
Gene ID: ENSG00000102606
  
Biological name :ARHGEF7
  
Synonyms : ARHGEF7 / Q14155 / Rho guanine nucleotide exchange factor 7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 111114559
Gene end: 111305737
  
Corresponding Affymetrix probe sets: 1562270_at (Human Genome U133 Plus 2.0 Array)   1562271_x_at (Human Genome U133 Plus 2.0 Array)   202547_s_at (Human Genome U133 Plus 2.0 Array)   202548_s_at (Human Genome U133 Plus 2.0 Array)   229642_at (Human Genome U133 Plus 2.0 Array)   235412_at (Human Genome U133 Plus 2.0 Array)   236416_at (Human Genome U133 Plus 2.0 Array)   239397_at (Human Genome U133 Plus 2.0 Array)   242999_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389890
Ensembl peptide - ENSP00000364893
Ensembl peptide - ENSP00000397068
Ensembl peptide - ENSP00000495631
Ensembl peptide - ENSP00000445384
Ensembl peptide - ENSP00000420592
Ensembl peptide - ENSP00000418235
Ensembl peptide - ENSP00000418067
Ensembl peptide - ENSP00000418043
Ensembl peptide - ENSP00000417596
Ensembl peptide - ENSP00000406732
Ensembl peptide - ENSP00000218789
Ensembl peptide - ENSP00000325994
Ensembl peptide - ENSP00000364875
Ensembl peptide - ENSP00000364888
Ensembl peptide - ENSP00000364891
NCBI entrez gene - 8874     See in Manteia.
OMIM - 605477
RefSeq - XM_017020829
RefSeq - NM_001320852
RefSeq - NM_001320853
RefSeq - NM_001320854
RefSeq - NM_001330597
RefSeq - NM_001330598
RefSeq - NM_001354048
RefSeq - NM_001354049
RefSeq - NM_001354050
RefSeq - NM_001354051
RefSeq - NM_001354052
RefSeq - NM_001354053
RefSeq - NM_001354057
RefSeq - NM_001354058
RefSeq - NM_001354059
RefSeq - NM_001354060
RefSeq - NM_003899
RefSeq - NM_145735
RefSeq - XM_006719956
RefSeq - XM_011521133
RefSeq - XM_017020814
RefSeq - XM_017020815
RefSeq - XM_017020816
RefSeq - XM_017020817
RefSeq - XM_017020818
RefSeq - XM_017020819
RefSeq - XM_017020820
RefSeq - XM_017020821
RefSeq - XM_017020822
RefSeq - XM_017020823
RefSeq - XM_017020824
RefSeq - XM_017020825
RefSeq - XM_017020826
RefSeq - XM_017020827
RefSeq - XM_017020828
RefSeq - NM_001113511
RefSeq - NM_001113512
RefSeq - NM_001113513
RefSeq - NM_001320851
RefSeq Peptide - NP_001307780
RefSeq Peptide - NP_001340982
RefSeq Peptide - NP_001340985
RefSeq Peptide - NP_001340986
RefSeq Peptide - NP_001340987
RefSeq Peptide - NP_001340988
RefSeq Peptide - NP_001340989
RefSeq Peptide - NP_003890
RefSeq Peptide - NP_663788
RefSeq Peptide - NP_001106983
RefSeq Peptide - NP_001106984
RefSeq Peptide - NP_001106985
RefSeq Peptide - NP_001307781
RefSeq Peptide - NP_001307782
RefSeq Peptide - NP_001307783
RefSeq Peptide - NP_001317526
RefSeq Peptide - NP_001317527
RefSeq Peptide - NP_001340975
RefSeq Peptide - NP_001340977
RefSeq Peptide - NP_001340978
RefSeq Peptide - NP_001340979
RefSeq Peptide - NP_001340980
RefSeq Peptide - NP_001340981
swissprot - E7EUY6
swissprot - E7EU80
swissprot - E7ENL8
swissprot - C9JDI6
swissprot - C9JAD7
swissprot - B1ANY6
swissprot - B1ALK7
swissprot - F6SJA5
swissprot - E9PDQ5
swissprot - Q14155
swissprot - A0A024RDY9
Ensembl - ENSG00000102606
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef7aENSDARG00000006299Danio rerio
 arhgef7bENSDARG00000073848Danio rerio
 ARHGEF7ENSGALG00000031009Gallus gallus
 Q9ES28ENSMUSG00000031511Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15052 / ARHGEF6 / Rac/Cdc42 guanine nucleotide exchange factor 6ENSG0000012967553
TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1ENSG0000015629917
Q96N96 / SPATA13 / spermatogenesis associated 13ENSG0000018295717
TIAM2 / Q8IVF5 / T cell lymphoma invasion and metastasis 2ENSG0000014642617
PREX1 / Q8TCU6 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1ENSG0000012412615
AL359736.1ENSG0000027316715
Q9NR80 / ARHGEF4 / Rho guanine nucleotide exchange factor 4ENSG0000013600214
VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3ENSG0000013421514
PREX2 / Q70Z35 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2ENSG0000004688914
VAV2 / P52735 / vav guanine nucleotide exchange factor 2ENSG0000016029314
VAV1 / P15498 / vav guanine nucleotide exchange factor 1ENSG0000014196814
O43307 / ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9ENSG0000013108912


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR032409  Rho guanine nucleotide exchange factor, coiled-coil domain
 IPR035789  Rho guanine nucleotide exchange factor 7, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010763 positive regulation of fibroblast migration HDA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0048041 focal adhesion assembly HDA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0060124 positive regulation of growth hormone secretion IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading HMP
 biological_processGO:1904424 regulation of GTP binding IMP
 biological_processGO:2000394 positive regulation of lamellipodium morphogenesis HMP
 cellular_componentGO:0000322 storage vacuole IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
NRAGE signals death through JNK
Rho GTPase cycle
Ephrin signaling
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000108262 GIT1 / Q9Y2X7 / GIT ArfGAP 1  / reaction / complex
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction
 ENSG00000102606 Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / reaction / complex
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / reaction / complex
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction / complex
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction






 

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