ENSG00000106263


Homo sapiens

Features
Gene ID: ENSG00000106263
  
Biological name :EIF3B
  
Synonyms : EIF3B / eukaryotic translation initiation factor 3 subunit B / P55884
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p22.3
Gene start: 2354086
Gene end: 2380745
  
Corresponding Affymetrix probe sets: 203462_x_at (Human Genome U133 Plus 2.0 Array)   208688_x_at (Human Genome U133 Plus 2.0 Array)   211501_s_at (Human Genome U133 Plus 2.0 Array)   236274_at (Human Genome U133 Plus 2.0 Array)   237457_at (Human Genome U133 Plus 2.0 Array)   242550_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380206
Ensembl peptide - ENSP00000408062
Ensembl peptide - ENSP00000407785
Ensembl peptide - ENSP00000354125
NCBI entrez gene - 8662     See in Manteia.
OMIM - 603917
RefSeq - XM_017012753
RefSeq - NM_001037283
RefSeq - NM_003751
RefSeq - XM_011515599
RefSeq - XM_011515600
RefSeq - XM_011515601
RefSeq - XM_017012752
RefSeq Peptide - NP_001032360
RefSeq Peptide - NP_003742
swissprot - C9JZG1
swissprot - C9JQN7
swissprot - P55884
swissprot - A0A024R821
Ensembl - ENSG00000106263
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif3baENSDARG00000059654Danio rerio
 eif3bbENSDARG00000074213Danio rerio
 EIF3BENSGALG00000040999Gallus gallus
 Eif3bENSMUSG00000056076Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR011400  Eukaryotic translation initiation factor 3 subunit B
 IPR013979  Translation initiation factor, beta propellor-like domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR034363  eIF3B, RNA recognition motif
 IPR035979  RNA-binding domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001732 formation of cytoplasmic translation initiation complex IEA
 biological_processGO:0002183 cytoplasmic translational initiation IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006446 regulation of translational initiation IDA
 biological_processGO:0075522 IRES-dependent viral translational initiation IDA
 biological_processGO:0075525 viral translational termination-reinitiation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005852 eukaryotic translation initiation factor 3 complex IDA
 cellular_componentGO:0016282 eukaryotic 43S preinitiation complex IEA
 cellular_componentGO:0033290 eukaryotic 48S preinitiation complex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003743 translation initiation factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031369 translation initiation factor binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity TAS


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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