ENSG00000108424


Homo sapiens

Features
Gene ID: ENSG00000108424
  
Biological name :KPNB1
  
Synonyms : karyopherin subunit beta 1 / KPNB1 / Q14974
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.32
Gene start: 47649476
Gene end: 47685505
  
Corresponding Affymetrix probe sets: 208974_x_at (Human Genome U133 Plus 2.0 Array)   208975_s_at (Human Genome U133 Plus 2.0 Array)   213507_s_at (Human Genome U133 Plus 2.0 Array)   213573_at (Human Genome U133 Plus 2.0 Array)   213574_s_at (Human Genome U133 Plus 2.0 Array)   213803_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438964
Ensembl peptide - ENSP00000463190
Ensembl peptide - ENSP00000464042
Ensembl peptide - ENSP00000464200
Ensembl peptide - ENSP00000290158
Ensembl peptide - ENSP00000438253
Ensembl peptide - ENSP00000462243
Ensembl peptide - ENSP00000463066
NCBI entrez gene - 3837     See in Manteia.
OMIM - 602738
RefSeq - NM_001276453
RefSeq - NM_002265
RefSeq Peptide - NP_001263382
RefSeq Peptide - NP_002256
swissprot - Q14974
swissprot - J3KS06
swissprot - J3KTM9
swissprot - J3QKQ5
swissprot - J3QR48
swissprot - J3QRG4
Ensembl - ENSG00000108424
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kpnb1ENSDARG00000104889Danio rerio
 KPNB1ENSGALG00000036962Gallus gallus
 Kpnb1ENSMUSG00000001440Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR000357  HEAT repeat
 IPR001494  Importin-beta, N-terminal domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation TAS
 biological_processGO:0006309 apoptotic DNA fragmentation TAS
 biological_processGO:0006606 protein import into nucleus IDA
 biological_processGO:0006607 NLS-bearing protein import into nucleus TAS
 biological_processGO:0006610 ribosomal protein import into nucleus IDA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007079 mitotic chromosome movement towards spindle pole IMP
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019054 modulation by virus of host process TAS
 biological_processGO:0030953 astral microtubule organization IMP
 biological_processGO:0031291 Ran protein signal transduction IMP
 biological_processGO:0040001 establishment of mitotic spindle localization IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0075733 intracellular transport of virus TAS
 biological_processGO:0090307 mitotic spindle assembly IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005643 nuclear pore TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0034399 nuclear periphery IBA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071782 endoplasmic reticulum tubular network IDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding TAS
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0008536 Ran GTPase binding IEA
 molecular_functionGO:0008565 protein transporter activity IBA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Nuclear import of Rev protein
Activation of DNA fragmentation factor
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / complex / reaction
 ENSG00000160049 DFFA / O00273 / DNA fragmentation factor subunit alpha  / reaction / complex
 ENSG00000132341 RAN / P62826 / RAN, member RAS oncogene family  / reaction / complex
 ENSG00000169598 DFFB / O76075 / DNA fragmentation factor subunit beta  / complex / reaction
 ENSG00000114030 KPNA1 / P52294 / karyopherin subunit alpha 1  / complex / reaction
 ENSG00000181163 NPM1 / P06748 / nucleophosmin 1  / reaction / complex
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr