ENSG00000108469


Homo sapiens

Features
Gene ID: ENSG00000108469
  
Biological name :RECQL5
  
Synonyms : O94762 / RECQL5 / RecQ like helicase 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.1
Gene start: 75626845
Gene end: 75667189
  
Corresponding Affymetrix probe sets: 1561720_at (Human Genome U133 Plus 2.0 Array)   210309_at (Human Genome U133 Plus 2.0 Array)   211468_s_at (Human Genome U133 Plus 2.0 Array)   221686_s_at (Human Genome U133 Plus 2.0 Array)   34063_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462678
Ensembl peptide - ENSP00000462547
Ensembl peptide - ENSP00000463099
Ensembl peptide - ENSP00000463701
Ensembl peptide - ENSP00000317636
Ensembl peptide - ENSP00000341983
Ensembl peptide - ENSP00000394820
Ensembl peptide - ENSP00000414933
Ensembl peptide - ENSP00000462077
Ensembl peptide - ENSP00000462248
Ensembl peptide - ENSP00000462291
NCBI entrez gene - 9400     See in Manteia.
OMIM - 603781
RefSeq - XM_017025344
RefSeq - NM_001003715
RefSeq - NM_001003716
RefSeq - NM_004259
RefSeq - XM_005257818
RefSeq - XM_005257823
RefSeq - XM_011525482
RefSeq - XM_017025343
RefSeq Peptide - NP_001003715
RefSeq Peptide - NP_001003716
RefSeq Peptide - NP_004250
swissprot - A0A024R8S8
swissprot - J3KRM6
swissprot - J3KS37
swissprot - J3KSL7
swissprot - J3KSV9
swissprot - J3KTQ2
swissprot - J3QLU0
swissprot - O94762
swissprot - A0A024R8M9
Ensembl - ENSG00000108469
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 recql5ENSDARG00000059556Danio rerio
 RECQL5ENSGALG00000002424Gallus gallus
 Q8VID5ENSMUSG00000020752Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BLM / P54132 / Bloom syndrome RecQ like helicaseENSG0000019729923
WRN / Q14191 / Werner syndrome RecQ like helicaseENSG0000016539219
RECQL / P46063 / RecQ like helicaseENSG0000000470017
RECQL4 / RecQ like helicase 4ENSG0000016095717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR004589  DNA helicase, ATP-dependent, RecQ type
 IPR010716  RecQ helicase-like 5
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032284  ATP-dependent DNA helicase RecQ, zinc-binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0000724 double-strand break repair via homologous recombination IBA
 biological_processGO:0006259 DNA metabolic process NAS
 biological_processGO:0006260 DNA replication IMP
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IDA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051304 chromosome separation IMP
 biological_processGO:0072757 cellular response to camptothecin IEA
 biological_processGO:1990414 replication-born double-strand break repair via sister chromatid exchange IEA
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm NAS
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016591 DNA-directed RNA polymerase II, holoenzyme IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003678 DNA helicase activity TAS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0009378 four-way junction helicase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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