ENSG00000110107


Homo sapiens

Features
Gene ID: ENSG00000110107
  
Biological name :PRPF19
  
Synonyms : pre-mRNA processing factor 19 / PRPF19 / Q9UMS4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q12.2
Gene start: 60890730
Gene end: 60906588
  
Corresponding Affymetrix probe sets: 203103_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000440266
Ensembl peptide - ENSP00000443031
Ensembl peptide - ENSP00000445435
Ensembl peptide - ENSP00000446259
Ensembl peptide - ENSP00000227524
NCBI entrez gene - 27339     See in Manteia.
OMIM - 608330
RefSeq - NM_014502
RefSeq Peptide - NP_055317
swissprot - Q9UMS4
swissprot - F5GY56
swissprot - F5H2I0
swissprot - H0YGF3
swissprot - H0YGZ5
Ensembl - ENSG00000110107
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prpf19ENSDARG00000015239Danio rerio
 ENSGALG00000036530Gallus gallus
 Prpf19ENSMUSG00000024735Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRPF4 / O43172 / pre-mRNA processing factor 4ENSG0000013687520
Q8N0X2 / SPAG16 / sperm associated antigen 16ENSG0000014445118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000772  Ricin B, lectin domain
 IPR001680  WD40 repeat
 IPR003613  U box domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013915  Pre-mRNA-splicing factor 19
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0000244 spliceosomal tri-snRNP complex assembly IDA
 biological_processGO:0000245 spliceosomal complex assembly IMP
 biological_processGO:0000349 generation of catalytic spliceosome for first transesterification step IBA
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0001833 inner cell mass cell proliferation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0008610 lipid biosynthetic process IEA
 biological_processGO:0010498 proteasomal protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IMP
 biological_processGO:0072422 signal transduction involved in DNA damage checkpoint IMP
 cellular_componentGO:0000974 Prp19 complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005662 DNA replication factor A complex IDA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0035861 site of double-strand break IDA
 cellular_componentGO:0071006 U2-type catalytic step 1 spliceosome IBA
 cellular_componentGO:0071007 U2-type catalytic step 2 spliceosome IDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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