ENSG00000113575


Homo sapiens

Features
Gene ID: ENSG00000113575
  
Biological name :PPP2CA
  
Synonyms : P67775 / PPP2CA / protein phosphatase 2 catalytic subunit alpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.1
Gene start: 134194334
Gene end: 134226142
  
Corresponding Affymetrix probe sets: 208652_at (Human Genome U133 Plus 2.0 Array)   235502_at (Human Genome U133 Plus 2.0 Array)   238719_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418447
Ensembl peptide - ENSP00000430869
Ensembl peptide - ENSP00000428816
NCBI entrez gene - 5515     See in Manteia.
OMIM - 176915
RefSeq - NM_002715
RefSeq Peptide - NP_002706
swissprot - E7ESG8
swissprot - E5RHP4
swissprot - B3KUN1
swissprot - P67775
Ensembl - ENSG00000113575
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPP2CAENSDARG00000053404Danio rerio
 PPP2CAENSGALG00000006462Gallus gallus
 P63330ENSMUSG00000020349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62714 / PPP2CB / protein phosphatase 2 catalytic subunit betaENSG0000010469597
PPP4C / P60510 / protein phosphatase 4 catalytic subunitENSG0000014992364


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000188 inactivation of MAPK activity NAS
 biological_processGO:0001932 regulation of protein phosphorylation NAS
 biological_processGO:0006275 regulation of DNA replication NAS
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006672 ceramide metabolic process NAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007084 mitotic nuclear envelope reassembly TAS
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0008380 RNA splicing NAS
 biological_processGO:0010033 response to organic substance NAS
 biological_processGO:0010288 response to lead ion TAS
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0019932 second-messenger-mediated signaling NAS
 biological_processGO:0030111 regulation of Wnt signaling pathway NAS
 biological_processGO:0030155 regulation of cell adhesion NAS
 biological_processGO:0030308 negative regulation of cell growth NAS
 biological_processGO:0035970 peptidyl-threonine dephosphorylation TAS
 biological_processGO:0040008 regulation of growth NAS
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein NAS
 biological_processGO:0045595 regulation of cell differentiation NAS
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0070262 peptidyl-serine dephosphorylation TAS
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IMP
 biological_processGO:1904526 regulation of microtubule binding NAS
 biological_processGO:1904528 positive regulation of microtubule binding ISS
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion NAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015630 microtubule cytoskeleton NAS
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0050811 GABA receptor binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Initiation of Nuclear Envelope Reformation
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin arent phosphorylated
S37 mutants of beta-catenin arent phosphorylated
S45 mutants of beta-catenin arent phosphorylated
T41 mutants of beta-catenin arent phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Glycolysis
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105568 P30153 / PPP2R1A / protein phosphatase 2 scaffold subunit Aalpha  / complex
 ENSG00000136158 SPRY2 / O43597 / sprouty RTK signaling antagonist 2  / complex
 ENSG00000175334 BANF1 / O75531 / barrier to autointegration factor 1  / reaction
 ENSG00000221914 P63151 / PPP2R2A / protein phosphatase 2 regulatory subunit Balpha  / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000079277 MKNK1 / Q9BUB5 / MAP kinase interacting serine/threonine kinase 1  / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction






 

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