ENSG00000114346


Homo sapiens

Features
Gene ID: ENSG00000114346
  
Biological name :ECT2
  
Synonyms : ECT2 / epithelial cell transforming 2 / Q9H8V3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q26.31
Gene start: 172750682
Gene end: 172821474
  
Corresponding Affymetrix probe sets: 219787_s_at (Human Genome U133 Plus 2.0 Array)   234992_x_at (Human Genome U133 Plus 2.0 Array)   237241_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403501
Ensembl peptide - ENSP00000403446
Ensembl peptide - ENSP00000411674
Ensembl peptide - ENSP00000443160
Ensembl peptide - ENSP00000415876
Ensembl peptide - ENSP00000412331
Ensembl peptide - ENSP00000412259
Ensembl peptide - ENSP00000412028
Ensembl peptide - ENSP00000232458
Ensembl peptide - ENSP00000376457
Ensembl peptide - ENSP00000389108
Ensembl peptide - ENSP00000391695
Ensembl peptide - ENSP00000397788
NCBI entrez gene - 1894     See in Manteia.
OMIM - 600586
RefSeq - XM_017005838
RefSeq - NM_001349102
RefSeq - NM_018098
RefSeq - XM_005247176
RefSeq - XM_006713523
RefSeq - XM_006713524
RefSeq - XM_011512514
RefSeq - XM_011512515
RefSeq - XM_011512516
RefSeq - XM_017005830
RefSeq - XM_017005831
RefSeq - XM_017005832
RefSeq - XM_017005833
RefSeq - XM_017005834
RefSeq - XM_017005835
RefSeq - XM_017005836
RefSeq - XM_017005837
RefSeq - NM_001258315
RefSeq - NM_001258316
RefSeq - NM_001349099
RefSeq Peptide - NP_001336028
RefSeq Peptide - NP_001336029
RefSeq Peptide - NP_001336031
RefSeq Peptide - NP_060568
RefSeq Peptide - NP_001245244
RefSeq Peptide - NP_001245245
RefSeq Peptide - NP_001336027
swissprot - Q9H8V3
swissprot - C9J0L6
swissprot - C9JTI2
swissprot - C9JDV9
swissprot - C9JDB4
swissprot - C9JB41
swissprot - C9J1C4
swissprot - H7C103
swissprot - H7C3G1
Ensembl - ENSG00000114346
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ect2ENSDARG00000007278Danio rerio
 ENSGALG00000009157Gallus gallus
 Ect2ENSMUSG00000027699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q92547 / TOPBP1 / DNA topoisomerase II binding protein 1ENSG0000016378119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001357  BRCT domain
 IPR011993  PH-like domain superfamily
 IPR026817  Guanine nucleotide exchange factor Ect2
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IMP
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0000910 cytokinesis IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0032467 positive regulation of cytokinesis IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus ISS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045666 positive regulation of neuron differentiation ISS
 biological_processGO:0045859 regulation of protein kinase activity IDA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0070830 bicellular tight junction assembly IMP
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:0071479 cellular response to ionizing radiation IDA
 biological_processGO:0090630 activation of GTPase activity IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0072686 mitotic spindle IDA
 cellular_componentGO:0097149 centralspindlin complex IDA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005096 GTPase activator activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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