ENSG00000115310


Homo sapiens

Features
Gene ID: ENSG00000115310
  
Biological name :RTN4
  
Synonyms : Q9NQC3 / reticulon 4 / RTN4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p16.1
Gene start: 54972187
Gene end: 55112621
  
Corresponding Affymetrix probe sets: 1556049_at (Human Genome U133 Plus 2.0 Array)   210968_s_at (Human Genome U133 Plus 2.0 Array)   211509_s_at (Human Genome U133 Plus 2.0 Array)   214629_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397808
Ensembl peptide - ENSP00000385650
Ensembl peptide - ENSP00000411628
Ensembl peptide - ENSP00000489133
Ensembl peptide - ENSP00000322147
Ensembl peptide - ENSP00000337838
Ensembl peptide - ENSP00000349944
Ensembl peptide - ENSP00000350365
Ensembl peptide - ENSP00000378107
Ensembl peptide - ENSP00000378109
Ensembl peptide - ENSP00000384471
Ensembl peptide - ENSP00000384825
NCBI entrez gene - 57142     See in Manteia.
OMIM - 604475
RefSeq - NM_207520
RefSeq - NM_001321859
RefSeq - NM_001321860
RefSeq - NM_001321861
RefSeq - NM_001321862
RefSeq - NM_001321863
RefSeq - NM_001321904
RefSeq - NM_007008
RefSeq - NM_020532
RefSeq - NM_153828
RefSeq - NM_207521
RefSeq - XM_005264434
RefSeq - XM_017004518
RefSeq - XM_017004519
RefSeq Peptide - NP_065393
RefSeq Peptide - NP_722550
RefSeq Peptide - NP_997403
RefSeq Peptide - NP_997404
RefSeq Peptide - NP_001308789
RefSeq Peptide - NP_001308788
RefSeq Peptide - NP_001308790
RefSeq Peptide - NP_001308791
RefSeq Peptide - NP_001308792
RefSeq Peptide - NP_001308833
RefSeq Peptide - NP_008939
swissprot - A0A0U1RQR6
swissprot - C9J685
swissprot - F8W914
swissprot - H7C106
swissprot - Q9NQC3
Ensembl - ENSG00000115310
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rtn4aENSDARG00000044601Danio rerio
 rtn4bENSDARG00000104347Danio rerio
 RTN4ENSGALG00000029261Gallus gallus
 Rtn4ENSMUSG00000020458Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RTN3 / O95197 / reticulon 3ENSG0000013331822
RTN1 / Q16799 / reticulon 1ENSG0000013997019
RTN2 / O75298 / reticulon 2ENSG0000012574413


Protein motifs (from Interpro)
Interpro ID Name
 IPR003388  Reticulon


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007413 axonal fasciculation IBA
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0021801 cerebral cortex radial glia guided migration ISS
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0030517 negative regulation of axon extension IDA
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0042981 regulation of apoptotic process NAS
 biological_processGO:0048694 positive regulation of collateral sprouting of injured axon IEA
 biological_processGO:0050771 negative regulation of axonogenesis TAS
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051292 nuclear pore complex assembly IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0051960 regulation of nervous system development IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IEA
 biological_processGO:0071786 endoplasmic reticulum tubular network organization IMP
 biological_processGO:0071787 endoplasmic reticulum tubular network formation IDA
 biological_processGO:1903860 negative regulation of dendrite extension IEA
 biological_processGO:1905552 positive regulation of protein localization to endoplasmic reticulum IDA
 biological_processGO:1905580 positive regulation of ERBB3 signaling pathway IMP
 biological_processGO:1905943 negative regulation of formation of growth cone in injured axon IEA
 biological_processGO:1990809 endoplasmic reticulum tubular network membrane organization IMP
 biological_processGO:2000172 regulation of branching morphogenesis of a nerve ISS
 cellular_componentGO:0005622 intracellular IMP
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044294 dendritic growth cone IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071782 endoplasmic reticulum tubular network IDA
 cellular_componentGO:0098826 endoplasmic reticulum tubular network membrane IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000040608 RTN4R / Q9BZR6 / reticulon 4 receptor  / reaction / complex
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction / complex
 ENSG00000141522 P52565 / ARHGDIA / Rho GDP dissociation inhibitor alpha  / reaction / complex
 ENSG00000169783 LINGO1 / Q96FE5 / leucine rich repeat and Ig domain containing 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr