ENSG00000120885


Homo sapiens

Features
Gene ID: ENSG00000120885
  
Biological name :CLU
  
Synonyms : CLU / clusterin / P10909
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.1
Gene start: 27596917
Gene end: 27615031
  
Corresponding Affymetrix probe sets: 1559228_at (Human Genome U133 Plus 2.0 Array)   208791_at (Human Genome U133 Plus 2.0 Array)   208792_s_at (Human Genome U133 Plus 2.0 Array)   222043_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428779
Ensembl peptide - ENSP00000453247
Ensembl peptide - ENSP00000431070
Ensembl peptide - ENSP00000431026
Ensembl peptide - ENSP00000430821
Ensembl peptide - ENSP00000429881
Ensembl peptide - ENSP00000429620
Ensembl peptide - ENSP00000429336
Ensembl peptide - ENSP00000429087
Ensembl peptide - ENSP00000315130
Ensembl peptide - ENSP00000385419
Ensembl peptide - ENSP00000427868
Ensembl peptide - ENSP00000428033
Ensembl peptide - ENSP00000428526
NCBI entrez gene - 1191     See in Manteia.
OMIM - 185430
RefSeq - XM_006716284
RefSeq - NM_001831
RefSeq Peptide - NP_001822
swissprot - E5RH61
swissprot - E5RGB0
swissprot - E5RG36
swissprot - E7ERK6
swissprot - H0YAS8
swissprot - H0YC35
swissprot - H0YLK8
swissprot - E7ETB4
swissprot - P10909
swissprot - E5RJD6
swissprot - E5RJZ5
Ensembl - ENSG00000120885
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cluENSDARG00000010434Danio rerio
 CLUENSGALG00000043051Gallus gallus
 CluENSMUSG00000022037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLUL1 / Q15846 / clusterin like 1ENSG0000007910124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000753  Clusterin-like
 IPR016014  Clusterin, N-terminal
 IPR016015  Clusterin, C-terminal
 IPR016016  Clusterin
 IPR027267  AH/BAR domain superfamily
 IPR033986  Clusterin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IDA
 biological_processGO:0001774 microglial cell activation IDA
 biological_processGO:0001836 release of cytochrome c from mitochondria IC
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006629 lipid metabolic process NAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006956 complement activation TAS
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0009615 response to virus IEP
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0017038 protein import IDA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0032286 central nervous system myelin maintenance IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032463 negative regulation of protein homooligomerization IMP
 biological_processGO:0032464 positive regulation of protein homooligomerization IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0043691 reverse cholesterol transport TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IGI
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051131 chaperone-mediated protein complex assembly IDA
 biological_processGO:0051788 response to misfolded protein IDA
 biological_processGO:0060548 negative regulation of cell death TAS
 biological_processGO:0061077 chaperone-mediated protein folding IDA
 biological_processGO:0061518 microglial cell proliferation IDA
 biological_processGO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy IC
 biological_processGO:0061741 chaperone-mediated protein transport involved in chaperone-mediated autophagy IC
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria TAS
 biological_processGO:1900221 regulation of amyloid-beta clearance IDA
 biological_processGO:1901214 regulation of neuron death IMP
 biological_processGO:1901216 positive regulation of neuron death IMP
 biological_processGO:1902004 positive regulation of amyloid-beta formation ISS
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:1902430 negative regulation of amyloid-beta formation IDA
 biological_processGO:1902847 regulation of neuronal signal transduction IMP
 biological_processGO:1902949 positive regulation of tau-protein kinase activity IMP
 biological_processGO:1902998 positive regulation of neurofibrillary tangle assembly IMP
 biological_processGO:1903573 negative regulation of response to endoplasmic reticulum stress IMP
 biological_processGO:1905892 negative regulation of cellular response to thapsigargin IMP
 biological_processGO:1905895 negative regulation of cellular response to tunicamycin IMP
 biological_processGO:1905907 negative regulation of amyloid fibril formation TAS
 biological_processGO:1905908 positive regulation of amyloid fibril formation TAS
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034366 spherical high-density lipoprotein particle IDA
 cellular_componentGO:0042583 chromaffin granule IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071944 cell periphery IDA
 cellular_componentGO:0072562 blood microparticle HDA
 cellular_componentGO:0097418 neurofibrillary tangle IDA
 cellular_componentGO:0097440 apical dendrite IDA
 cellular_componentGO:0106003 amyloid-beta complex IPI
 molecular_functionGO:0001540 amyloid-beta binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0048156 tau protein binding IPI
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IPI
 molecular_functionGO:0051087 chaperone binding ISS
 molecular_functionGO:0051787 misfolded protein binding IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Terminal pathway of complement
Antimicrobial peptides
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000021852 C8B / P07358 / complement C8 beta chain  / complex / reaction
 ENSG00000106804 C5 / P01031 / complement C5  / complex / reaction
 ENSG00000101448 EPPIN / O95925 / epididymal peptidase inhibitor  / complex
 ENSG00000157131 C8A / P07357 / complement C8 alpha chain  / complex / reaction
 ENSG00000039537 C6 / P13671 / complement C6  / complex / reaction
 ENSG00000176919 C8G / P07360 / complement C8 gamma chain  / complex / reaction
 ENSG00000112936 C7 / P10643 / complement C7  / complex / reaction
 ENSG00000124233 SEMG1 / P04279 / semenogelin I  / complex
 ENSG00000012223 LTF / P02788 / lactotransferrin  / complex
 ENSG00000120885 CLU / P10909 / clusterin  / complex
 ENSG00000113600 C9 / P02748 / complement C9  / reaction / complex






 

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