ENSG00000122884


Homo sapiens

Features
Gene ID: ENSG00000122884
  
Biological name :P4HA1
  
Synonyms : P13674 / P4HA1 / prolyl 4-hydroxylase subunit alpha 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q22.1
Gene start: 73007217
Gene end: 73096974
  
Corresponding Affymetrix probe sets: 207543_s_at (Human Genome U133 Plus 2.0 Array)   243335_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000307318
Ensembl peptide - ENSP00000378353
Ensembl peptide - ENSP00000414464
Ensembl peptide - ENSP00000263556
Ensembl peptide - ENSP00000362099
NCBI entrez gene - 5033     See in Manteia.
OMIM - 176710
RefSeq - NM_001017962
RefSeq - NM_000917
RefSeq - NM_001142595
RefSeq - NM_001142596
RefSeq Peptide - NP_000908
RefSeq Peptide - NP_001017962
RefSeq Peptide - NP_001136067
RefSeq Peptide - NP_001136068
swissprot - P13674
swissprot - Q5VSQ6
Ensembl - ENSG00000122884
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p4ha1aENSDARG00000033537Danio rerio
 p4ha1bENSDARG00000071082Danio rerio
 P4HA1ENSGALG00000004325Gallus gallus
 P4ha1ENSMUSG00000019916Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P4HA2 / O15460 / prolyl 4-hydroxylase subunit alpha 2ENSG0000007268263
P4HA3 / Q7Z4N8 / prolyl 4-hydroxylase subunit alpha 3ENSG0000014938032


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013547  Prolyl 4-hydroxylase alpha-subunit, N-terminal
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016222 procollagen-proline 4-dioxygenase complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0004656 procollagen-proline 4-dioxygenase activity TAS
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122884 P4HA1 / P13674 / prolyl 4-hydroxylase subunit alpha 1  / complex
 ENSG00000185624 P4HB / P07237 / prolyl 4-hydroxylase subunit beta  / complex / reaction
 ENSG00000072682 P4HA2 / O15460 / prolyl 4-hydroxylase subunit alpha 2  / complex
 ENSG00000123500 Q03692 / COL10A1 / collagen type X alpha 1 chain  / reaction
 ENSG00000149380 P4HA3 / Q7Z4N8 / prolyl 4-hydroxylase subunit alpha 3  / complex
 ENSG00000168542 COL3A1 / P02461 / collagen type III alpha 1 chain  / reaction
 ENSG00000164692 COL1A2 / P08123 / collagen type I alpha 2 chain  / reaction
 ENSG00000108821 COL1A1 / P02452 / collagen type I alpha 1 chain  / reaction






 

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