ENSG00000123416


Homo sapiens

Features
Gene ID: ENSG00000123416
  
Biological name :TUBA1B
  
Synonyms : P68363 / TUBA1B / tubulin alpha 1b
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.12
Gene start: 49127782
Gene end: 49131397
  
Corresponding Affymetrix probe sets: 201090_x_at (Human Genome U133 Plus 2.0 Array)   211058_x_at (Human Genome U133 Plus 2.0 Array)   211072_x_at (Human Genome U133 Plus 2.0 Array)   212639_x_at (Human Genome U133 Plus 2.0 Array)   213646_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448045
Ensembl peptide - ENSP00000448648
Ensembl peptide - ENSP00000449325
Ensembl peptide - ENSP00000449460
Ensembl peptide - ENSP00000449748
Ensembl peptide - ENSP00000336799
NCBI entrez gene - 10376     See in Manteia.
OMIM - 602530
RefSeq - NM_006082
RefSeq Peptide - NP_006073
swissprot - P68363
swissprot - F8VRK0
swissprot - F8VU66
swissprot - F8VVB9
swissprot - F8VWV9
swissprot - F8VX09
Ensembl - ENSG00000123416
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tuba2ENSDARG00000045014Danio rerio
 P05213ENSMUSG00000023004Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q71U36 / TUBA1A / tubulin alpha 1aENSG00000167552100
Q9BQE3 / TUBA1C / tubulin alpha 1cENSG0000016755398
Q13748 / TUBA3D / tubulin alpha 3dENSG0000007588697
Q13748 / TUBA3C / tubulin alpha 3cENSG0000019803397
Q6PEY2 / TUBA3E / tubulin alpha 3eENSG0000015208696
P68366 / TUBA4A / tubulin alpha 4aENSG0000012782496
Q9H853 / TUBA4B / tubulin alpha 4bENSG0000024391039


Protein motifs (from Interpro)
Interpro ID Name
 IPR000217  Tubulin
 IPR002452  Alpha tubulin
 IPR003008  Tubulin/FtsZ, GTPase domain
 IPR008280  Tubulin/FtsZ, C-terminal
 IPR017975  Tubulin, conserved site
 IPR018316  Tubulin/FtsZ, 2-layer sandwich domain
 IPR036525  Tubulin/FtsZ, GTPase domain superfamily
 IPR037103  Tubulin/FtsZ, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0030705 cytoskeleton-dependent intracellular transport TAS
 biological_processGO:0051301 cell division TAS
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005198 structural molecule activity TAS
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Recruitment of NuMA to mitotic centrosomes
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Hedgehog off state
Cilium Assembly
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
Carboxyterminal post-translational modifications of tubulin
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr