ENSG00000130669


Homo sapiens

Features
Gene ID: ENSG00000130669
  
Biological name :PAK4
  
Synonyms : O96013 / p21 (RAC1) activated kinase 4 / PAK4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 39125770
Gene end: 39182816
  
Corresponding Affymetrix probe sets: 203154_s_at (Human Genome U133 Plus 2.0 Array)   215326_at (Human Genome U133 Plus 2.0 Array)   33814_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472061
Ensembl peptide - ENSP00000471318
Ensembl peptide - ENSP00000472862
Ensembl peptide - ENSP00000473215
Ensembl peptide - ENSP00000326864
Ensembl peptide - ENSP00000351049
Ensembl peptide - ENSP00000353625
Ensembl peptide - ENSP00000469413
Ensembl peptide - ENSP00000470284
Ensembl peptide - ENSP00000471157
NCBI entrez gene - 10298     See in Manteia.
OMIM - 605451
RefSeq - XM_011526320
RefSeq - NM_001014831
RefSeq - NM_001014832
RefSeq - NM_001014834
RefSeq - NM_001014835
RefSeq - NM_005884
RefSeq - XM_011526316
RefSeq - XM_011526317
RefSeq - XM_011526318
RefSeq - XM_011526319
RefSeq Peptide - NP_001014831
RefSeq Peptide - NP_001014834
RefSeq Peptide - NP_001014835
RefSeq Peptide - NP_005875
RefSeq Peptide - NP_001014832
swissprot - M0R3G6
swissprot - A0A024R0J1
swissprot - O96013
swissprot - A0A024R0L8
swissprot - M0R0L9
swissprot - M0R1R1
swissprot - M0R2X4
Ensembl - ENSG00000130669
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pak4ENSDARG00000018110Danio rerio
 PAK4ENSGALG00000031328Gallus gallus
 Pak4ENSMUSG00000030602Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PAK5 / Q9P286 / p21 (RAC1) activated kinase 5ENSG0000010134963
PAK6 / Q9NQU5 / p21 (RAC1) activated kinase 6ENSG0000013784355
BUB1B-PAK6 / BUB1B-PAK6 readthroughENSG0000025928855
PAK3 / O75914 / p21 (RAC1) activated kinase 3ENSG0000007726433
PAK1 / Q13153 / p21 (RAC1) activated kinase 1ENSG0000014926932
PAK2 / Q13177 / p21 (RAC1) activated kinase 2ENSG0000018037032
TAOK1 / Q7L7X3 / TAO kinase 1ENSG0000016055120
TAOK2 / Q9UL54 / TAO kinase 2ENSG0000014993019
TAOK3 / Q9H2K8 / TAO kinase 3ENSG0000013509019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016049 cell growth TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration TAS
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0060996 dendritic spine development IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005925 focal adhesion HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity NAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IDA


Pathways (from Reactome)
Pathway description
Activation of RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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