ENSG00000130812


Homo sapiens

Features
Gene ID: ENSG00000130812
  
Biological name :ANGPTL6
  
Synonyms : angiopoietin like 6 / ANGPTL6 / Q8NI99
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.2
Gene start: 10092338
Gene end: 10102796
  
Corresponding Affymetrix probe sets: 223967_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467930
Ensembl peptide - ENSP00000253109
Ensembl peptide - ENSP00000465597
NCBI entrez gene - 83854     See in Manteia.
OMIM - 609336
RefSeq - XM_017027347
RefSeq - XM_005260091
RefSeq - XM_011528347
RefSeq - XM_011528348
RefSeq - XM_011528349
RefSeq - XM_011528350
RefSeq - NM_001321411
RefSeq - NM_031917
RefSeq Peptide - NP_001308340
RefSeq Peptide - NP_114123
swissprot - K7EKF6
swissprot - Q8NI99
swissprot - A0A024R7A9
Ensembl - ENSG00000130812
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angptl6ENSDARG00000020265Danio rerio
 Q8R0Z6ENSMUSG00000038742Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UKU9 / ANGPTL2 / angiopoietin like 2ENSG0000013685946
O95841 / ANGPTL1 / angiopoietin like 1ENSG0000011619442
ANGPT4 / Q9Y264 / angiopoietin 4ENSG0000010128028
FIBCD1 / Q8N539 / fibrinogen C domain containing 1ENSG0000013072027
ANGPT1 / Q15389 / angiopoietin 1ENSG0000015418826
FCN3 / O75636 / ficolin 3ENSG0000014274825
ANGPT2 / O15123 / angiopoietin 2ENSG0000009187925
FCN1 / O00602 / ficolin 1ENSG0000008526524
FCN2 / Q15485 / ficolin 2ENSG0000016033924
FGL2 / Q14314 / fibrinogen like 2ENSG0000012795123
MFAP4 / P55083 / microfibril associated protein 4ENSG0000016648222
O43827 / ANGPTL7 / angiopoietin like 7ENSG0000017181921


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0070062 extracellular exosome HDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000822 Hypertension "High blood pressure." [HPO:curators]
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 HP:0001123 Visual field defects 
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 HP:0001250 Seizures "Seizures are an intermittent `abnormality of the central nervous system` (FMA:HP:0002011) due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements." [HPO:probinson]
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 HP:0001269 Hemiparesis "Relatively mild weakness in the arm, leg, and in some cases the face on one side of the body." [HPO:curators]
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 HP:0002138 Subarachnoid hemorrhage 
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 HP:0002326 Transient ischemic attack 
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 HP:0002363 Abnormality of the brainstem 
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 HP:0002616 Aortic root dilatation 
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 HP:0002621 Atherosclerosis "A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow." [HPO:curators]
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 HP:0002647 Aortic dissection "Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta." [HPO:curators]
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 HP:0007029 Cerebral berry aneurysms 
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 HP:0012246 Oculomotor nerve palsy "Reduced ability to control the movement of the eye associated with damage to the third cranial nerve (the oculomotor nerve)." [HPO:probinson]
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 HP:0012518 Abnormality of circle of Willis "An anomaly of the `circle of Willis` (FMA:50454), also known as the cerebral arterial circle." [HPO:probinson]
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 HP:0040197 Encephalomalacia "Encephalomalacia is the softening or loss of brain tissue after cerebral infarction, cerebral ischemia, infection, craniocerebral trauma, or other injury." [PhenoTips:CHum]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr