ENSG00000131626


Homo sapiens

Features
Gene ID: ENSG00000131626
  
Biological name :PPFIA1
  
Synonyms : PPFIA1 / PTPRF interacting protein alpha 1 / Q13136
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.3
Gene start: 70270700
Gene end: 70385312
  
Corresponding Affymetrix probe sets: 202065_s_at (Human Genome U133 Plus 2.0 Array)   202066_at (Human Genome U133 Plus 2.0 Array)   210235_s_at (Human Genome U133 Plus 2.0 Array)   210236_at (Human Genome U133 Plus 2.0 Array)   242990_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435752
Ensembl peptide - ENSP00000434692
Ensembl peptide - ENSP00000435978
Ensembl peptide - ENSP00000496327
Ensembl peptide - ENSP00000490647
Ensembl peptide - ENSP00000437024
Ensembl peptide - ENSP00000253925
Ensembl peptide - ENSP00000374198
Ensembl peptide - ENSP00000432065
Ensembl peptide - ENSP00000432722
Ensembl peptide - ENSP00000432913
Ensembl peptide - ENSP00000433114
Ensembl peptide - ENSP00000433619
Ensembl peptide - ENSP00000434445
NCBI entrez gene - 8500     See in Manteia.
OMIM - 611054
RefSeq - XM_017018450
RefSeq - XM_011545307
RefSeq - XM_011545308
RefSeq - XM_011545309
RefSeq - XM_011545310
RefSeq - XM_011545311
RefSeq - XM_011545312
RefSeq - XM_011545313
RefSeq - XM_011545314
RefSeq - XM_011545315
RefSeq - XM_011545316
RefSeq - XM_011545317
RefSeq - XM_011545319
RefSeq - XM_017018448
RefSeq - XM_017018449
RefSeq - NM_003626
RefSeq - NM_177423
RefSeq - XM_006718716
RefSeq - XM_011545306
RefSeq Peptide - NP_003617
RefSeq Peptide - NP_803172
swissprot - E9PID5
swissprot - H0YD39
swissprot - H0YD72
swissprot - H0YDW2
swissprot - H0YDZ8
swissprot - E9PPF6
swissprot - H0YEK0
swissprot - H0YF15
swissprot - Q13136
swissprot - A0A1B0GVT3
swissprot - H0YEF9
swissprot - E9PJZ7
Ensembl - ENSG00000131626
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppfia1ENSDARG00000098674Danio rerio
 PPFIA1ENSGALG00000035774Gallus gallus
 Ppfia1ENSMUSG00000037519Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O75334 / PPFIA2 / PTPRF interacting protein alpha 2ENSG0000013922070
O75335 / PPFIA4 / PTPRF interacting protein alpha 4ENSG0000014384764
O75145 / PPFIA3 / PTPRF interacting protein alpha 3ENSG0000017738063
KAZN / Q674X7 / kazrin, periplakin interacting proteinENSG0000018933719
Q8ND30 / PPFIBP2 / PPFIA binding protein 2ENSG0000016638718
Q86W92 / PPFIBP1 / PPFIA binding protein 1ENSG0000011084118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029515  LAR-interacting protein, Liprin
 IPR030438  Liprin-alpha-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0051497 negative regulation of stress fiber assembly IMP
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048786 presynaptic active zone TAS
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142949 PTPRF / P10586 / protein tyrosine phosphatase, receptor type F  / complex / reaction
 ENSG00000198722 O14795 / UNC13B / unc-13 homolog B  / complex
 ENSG00000005379 O95153 / TSPOAP1 / TSPO associated protein 1  / complex
 ENSG00000153707 PTPRD / P23468 / protein tyrosine phosphatase, receptor type D  / complex / reaction
 ENSG00000105426 PTPRS / Q13332 / protein tyrosine phosphatase, receptor type S  / reaction / complex
 ENSG00000079841 RIMS1 / Q86UR5 / regulating synaptic membrane exocytosis 1  / complex






 

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contact: otassy@igbmc.fr