ENSG00000134308


Homo sapiens

Features
Gene ID: ENSG00000134308
  
Biological name :YWHAQ
  
Synonyms : P27348 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta / YWHAQ
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p25.1
Gene start: 9583972
Gene end: 9631014
  
Corresponding Affymetrix probe sets: 200693_at (Human Genome U133 Plus 2.0 Array)   212426_s_at (Human Genome U133 Plus 2.0 Array)   213699_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000238081
Ensembl peptide - ENSP00000398990
Ensembl peptide - ENSP00000371267
NCBI entrez gene - 10971     See in Manteia.
OMIM - 609009
RefSeq - NM_006826
RefSeq Peptide - NP_006817
swissprot - E9PG15
swissprot - P27348
Ensembl - ENSG00000134308
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ywhaqaENSDARG00000042539Danio rerio
 ywhaqbENSDARG00000023323Danio rerio
 YWHAQENSGALG00000016433Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaENSG0000016691382
YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zetaENSG0000016492480
SFN / P31947 / stratifinENSG0000017579370
YWHAH / Q04917 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaENSG0000012824570
YWHAG / P61981 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gammaENSG0000017002769
YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonENSG0000010895365


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134308 YWHAQ / P27348 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta  / complex






 

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contact: otassy@igbmc.fr