ENSG00000135336


Homo sapiens

Features
Gene ID: ENSG00000135336
  
Biological name :ORC3
  
Synonyms : ORC3 / origin recognition complex subunit 3 / Q9UBD5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q15
Gene start: 87590067
Gene end: 87667453
  
Corresponding Affymetrix probe sets: 210028_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000257789
Ensembl peptide - ENSP00000376586
Ensembl peptide - ENSP00000444695
Ensembl peptide - ENSP00000475988
NCBI entrez gene - 23595     See in Manteia.
OMIM - 604972
RefSeq - XM_017010640
RefSeq - NM_001197259
RefSeq - NM_012381
RefSeq - NM_181837
RefSeq - XM_017010635
RefSeq - XM_017010636
RefSeq - XM_017010637
RefSeq - XM_017010638
RefSeq - XM_017010639
RefSeq - XM_005248704
RefSeq - XM_005248705
RefSeq - XM_005248706
RefSeq - XM_011535651
RefSeq - XM_017010632
RefSeq - XM_017010633
RefSeq - XM_017010634
RefSeq Peptide - NP_036513
RefSeq Peptide - NP_862820
RefSeq Peptide - NP_001184188
swissprot - Q9UBD5
swissprot - U3KQL3
Ensembl - ENSG00000135336
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 orc3ENSDARG00000008805Danio rerio
 ORC3ENSGALG00000015800Gallus gallus
 Orc3ENSMUSG00000040044Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR020795  Origin recognition complex, subunit 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0061351 neural precursor cell proliferation IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000808 origin recognition complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005656 nuclear pre-replicative complex IBA
 cellular_componentGO:0005664 nuclear origin of replication recognition complex IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0031261 DNA replication preinitiation complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003688 DNA replication origin binding TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115942 ORC2 / Q13416 / origin recognition complex subunit 2  / reaction / complex
 ENSG00000091651 ORC6 / Q9Y5N6 / origin recognition complex subunit 6  / reaction
 ENSG00000115947 ORC4 / O43929 / origin recognition complex subunit 4  / reaction / complex
 ENSG00000164815 ORC5 / O43913 / origin recognition complex subunit 5  / complex / reaction
 ENSG00000085840 ORC1 / Q13415 / origin recognition complex subunit 1  / reaction / complex






 

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