ENSG00000135720


Homo sapiens

Features
Gene ID: ENSG00000135720
  
Biological name :DYNC1LI2
  
Synonyms : DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2 / O43237
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.1
Gene start: 66720893
Gene end: 66751798
  
Corresponding Affymetrix probe sets: 203590_at (Human Genome U133 Plus 2.0 Array)   213162_at (Human Genome U133 Plus 2.0 Array)   224614_at (Human Genome U133 Plus 2.0 Array)   224616_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462224
Ensembl peptide - ENSP00000462017
Ensembl peptide - ENSP00000462434
Ensembl peptide - ENSP00000463124
Ensembl peptide - ENSP00000258198
Ensembl peptide - ENSP00000394289
Ensembl peptide - ENSP00000408566
Ensembl peptide - ENSP00000457464
Ensembl peptide - ENSP00000457707
NCBI entrez gene - 1783     See in Manteia.
OMIM - 611406
RefSeq - XM_017023008
RefSeq - NM_001286157
RefSeq - NM_001323955
RefSeq - NM_006141
RefSeq Peptide - NP_006132
RefSeq Peptide - NP_001273086
RefSeq Peptide - NP_001310884
swissprot - J3QKK5
swissprot - O43237
swissprot - A0A024R6Z0
swissprot - B4E2E0
swissprot - H3BU48
swissprot - J3KRI4
swissprot - H3BUM4
swissprot - J3KRZ2
swissprot - J3KSD2
Ensembl - ENSG00000135720
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dync1li2ENSDARG00000035924Danio rerio
 ENSGALG00000022206Gallus gallus
 DYNC1LI2ENSGALG00000005241Gallus gallus
 Q6PDL0ENSMUSG00000035770Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1ENSG0000014463565


Protein motifs (from Interpro)
Interpro ID Name
 IPR008467  Dynein 1 light intermediate chain
 IPR022780  Dynein family light intermediate chain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IBA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051642 centrosome localization IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005868 cytoplasmic dynein complex IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030286 dynein complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0045504 dynein heavy chain binding IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR)
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex
 ENSG00000197102 Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1  / complex
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / complex / reaction
 ENSG00000141429 GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1  / complex / reaction
 ENSG00000166847 DCTN5 / Q9BTE1 / dynactin subunit 5  / complex
 ENSG00000104671 DCTN6 / O00399 / dynactin subunit 6  / complex
 ENSG00000077549 CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit  / complex
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex
 ENSG00000204843 DCTN1 / Q14203 / dynactin subunit 1  / complex
 ENSG00000131966 ACTR10 / Q9NZ32 / actin related protein 10 homolog  / complex
 ENSG00000143641 GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2  / complex / reaction
 ENSG00000138107 ACTR1A / P61163 / ARP1 actin related protein 1 homolog A  / complex
 ENSG00000116489 CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1  / complex
 ENSG00000077380 Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2  / complex
 ENSG00000151746 BICD1 / Q96G01 / BICD cargo adaptor 1  / reaction / complex
 ENSG00000144635 Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1  / complex
 ENSG00000177938 CAPZA3 / Q96KX2 / capping actin protein of muscle Z-line alpha subunit 3  / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / complex
 ENSG00000132912 DCTN4 / Q9UJW0 / dynactin subunit 4  / complex
 ENSG00000175203 DCTN2 / Q13561 / dynactin subunit 2  / complex
 ENSG00000198898 CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2  / complex
 ENSG00000137100 DCTN3 / O75935 / dynactin subunit 3  / complex
 ENSG00000158560 O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1  / complex
 ENSG00000135720 O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2  / complex






 

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