ENSG00000137575


Homo sapiens

Features
Gene ID: ENSG00000137575
  
Biological name :SDCBP
  
Synonyms : O00560 / SDCBP / syndecan binding protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q12.1
Gene start: 58552924
Gene end: 58582860
  
Corresponding Affymetrix probe sets: 200958_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411771
Ensembl peptide - ENSP00000409288
Ensembl peptide - ENSP00000428184
Ensembl peptide - ENSP00000487245
Ensembl peptide - ENSP00000430730
Ensembl peptide - ENSP00000260130
Ensembl peptide - ENSP00000395351
Ensembl peptide - ENSP00000397820
NCBI entrez gene - 6386     See in Manteia.
OMIM - 602217
RefSeq - XM_017013728
RefSeq - NM_001007067
RefSeq - NM_001007068
RefSeq - NM_001007069
RefSeq - NM_001007070
RefSeq - NM_001330537
RefSeq - NM_001348340
RefSeq - NM_001348341
RefSeq - NM_005625
RefSeq - XM_011517571
RefSeq - XM_017013727
RefSeq Peptide - NP_001317466
RefSeq Peptide - NP_001335269
RefSeq Peptide - NP_001335270
RefSeq Peptide - NP_005616
RefSeq Peptide - NP_001007069
RefSeq Peptide - NP_001007068
RefSeq Peptide - NP_001007070
RefSeq Peptide - NP_001007071
swissprot - O00560
swissprot - E9PBU7
swissprot - B4DHN5
swissprot - G5EA09
swissprot - A0A024R7Z5
Ensembl - ENSG00000137575
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdcbpENSDARG00000030097Danio rerio
 SDCBPENSGALG00000015436Gallus gallus
 SdcbpENSMUSG00000028249Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H190 / SDCBP2 / syndecan binding protein 2ENSG0000012577554


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR030528  Syntenin-1
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002091 negative regulation of receptor internalization IMP
 biological_processGO:0006612 protein targeting to membrane NAS
 biological_processGO:0006930 substrate-dependent cell migration, cell extension NAS
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IMP
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042327 positive regulation of phosphorylation IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046330 positive regulation of JNK cascade IC
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 biological_processGO:1903553 positive regulation of extracellular exosome assembly IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton NAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005895 interleukin-5 receptor complex IEA
 cellular_componentGO:0005912 adherens junction NAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0072562 blood microparticle HDA
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005137 interleukin-5 receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008093 cytoskeletal adaptor activity NAS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0042043 neurexin family protein binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0045545 syndecan binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Ephrin signaling
Neurofascin interactions
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction / complex
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / reaction / complex
 ENSG00000163531 NFASC / O94856 / neurofascin  / complex / reaction






 

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