ENSG00000138674


Homo sapiens

Features
Gene ID: ENSG00000138674
  
Biological name :SEC31A
  
Synonyms : O94979 / SEC31A / SEC31 homolog A, COPII coat complex component
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q21.22
Gene start: 82818661
Gene end: 82901166
  
Corresponding Affymetrix probe sets: 200945_s_at (Human Genome U133 Plus 2.0 Array)   210616_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425056
Ensembl peptide - ENSP00000476156
Ensembl peptide - ENSP00000475765
Ensembl peptide - ENSP00000426950
Ensembl peptide - ENSP00000426943
Ensembl peptide - ENSP00000426886
Ensembl peptide - ENSP00000426569
Ensembl peptide - ENSP00000426562
Ensembl peptide - ENSP00000425999
Ensembl peptide - ENSP00000425555
Ensembl peptide - ENSP00000425140
Ensembl peptide - ENSP00000425095
Ensembl peptide - ENSP00000425064
Ensembl peptide - ENSP00000264405
Ensembl peptide - ENSP00000309070
Ensembl peptide - ENSP00000337602
Ensembl peptide - ENSP00000347329
Ensembl peptide - ENSP00000378721
Ensembl peptide - ENSP00000400926
Ensembl peptide - ENSP00000408027
Ensembl peptide - ENSP00000421001
Ensembl peptide - ENSP00000421464
Ensembl peptide - ENSP00000421633
Ensembl peptide - ENSP00000422267
Ensembl peptide - ENSP00000422371
Ensembl peptide - ENSP00000422563
Ensembl peptide - ENSP00000422797
Ensembl peptide - ENSP00000424336
Ensembl peptide - ENSP00000424451
Ensembl peptide - ENSP00000424635
NCBI entrez gene - 22872     See in Manteia.
OMIM - 610257
RefSeq - NM_016211
RefSeq - NM_001318120
RefSeq - NM_001318119
RefSeq - NM_001300745
RefSeq - NM_001300744
RefSeq - NM_001191049
RefSeq - NM_001077208
RefSeq - NM_001077207
RefSeq - NM_001077206
RefSeq Peptide - NP_001070675
RefSeq Peptide - NP_001070674
RefSeq Peptide - NP_001070676
RefSeq Peptide - NP_001177978
RefSeq Peptide - NP_001287673
RefSeq Peptide - NP_001287674
RefSeq Peptide - NP_001305048
RefSeq Peptide - NP_001305049
RefSeq Peptide - NP_057295
swissprot - H7BXG7
swissprot - A0A024RDH6
swissprot - D6RAB3
swissprot - D6RBT0
swissprot - D6RCQ9
swissprot - D6RE64
swissprot - D6REA9
swissprot - D6REC0
swissprot - D6REX3
swissprot - D6RHE8
swissprot - U3KQC9
swissprot - D6RHZ5
swissprot - U3KQR3
swissprot - O94979
swissprot - A0A024RDD3
swissprot - H0Y8V7
swissprot - H0Y8W8
swissprot - H0Y9K1
swissprot - H0Y9T9
swissprot - H0Y9V3
swissprot - H0YAB3
swissprot - H0YAF5
Ensembl - ENSG00000138674
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sec31aENSDARG00000021082Danio rerio
 SEC31AENSGALG00000040484Gallus gallus
 Q3UPL0ENSMUSG00000035325Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NQW1 / SEC31B / SEC31 homolog B, COPII coat complex componentENSG0000007582645


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR024298  Ancestral coatomer element 1, Sec16/Sec31
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport NAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:0090110 cargo loading into COPII-coated vesicle IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030120 vesicle coat IDA
 cellular_componentGO:0030127 COPII vesicle coat NAS
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070971 endoplasmic reticulum exit site IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0048306 calcium-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
MHC class II antigen presentation
XBP1(S) activates chaperone genes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / complex / reaction
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / reaction / complex
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000120341 Q96JE7 / SEC16B / SEC16 homolog B, endoplasmic reticulum export factor  / reaction / complex
 ENSG00000138069 RAB1A / P62820 / RAB1A, member RAS oncogene family  / complex / reaction
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / reaction / complex
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction / complex
 ENSG00000114745 Q9BQQ3 / GORASP1 / golgi reassembly stacking protein 1  / reaction / complex
 ENSG00000107651 Q9Y6Y8 / SEC23IP / SEC23 interacting protein  / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex / reaction
 ENSG00000138674 O94979 / SEC31A / SEC31 homolog A, COPII coat complex component  / complex
 ENSG00000152700 SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B  / complex / reaction
 ENSG00000148396 O15027 / SEC16A / SEC16 homolog A, endoplasmic reticulum export factor  / reaction / complex
 ENSG00000114354 TFG / Q92734 / TRK-fused gene  / complex / reaction
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / complex / reaction
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / reaction / complex
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / complex / reaction
 ENSG00000157020 SEC13 / P55735 / SEC13 homolog, nuclear pore and COPII coat complex component  / complex / reaction
 ENSG00000265808 O75396 / SEC22B / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)  / complex / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / complex / reaction
 ENSG00000141551 CSNK1D / P48730 / casein kinase 1 delta  / reaction






 

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