ENSG00000138750


Homo sapiens

Features
Gene ID: ENSG00000138750
  
Biological name :NUP54
  
Synonyms : nucleoporin 54 / NUP54 / Q7Z3B4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q21.1
Gene start: 76114659
Gene end: 76148515
  
Corresponding Affymetrix probe sets: 215213_at (Human Genome U133 Plus 2.0 Array)   218256_s_at (Human Genome U133 Plus 2.0 Array)   231301_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421304
Ensembl peptide - ENSP00000426609
Ensembl peptide - ENSP00000425243
Ensembl peptide - ENSP00000424389
Ensembl peptide - ENSP00000424172
Ensembl peptide - ENSP00000421932
Ensembl peptide - ENSP00000264883
NCBI entrez gene - 53371     See in Manteia.
OMIM - 607607
RefSeq - XM_006714237
RefSeq - XM_017008294
RefSeq - XM_011532034
RefSeq - NM_001278603
RefSeq - NM_017426
RefSeq - XM_017008295
RefSeq - XM_011532033
RefSeq Peptide - NP_001265532
RefSeq Peptide - NP_059122
swissprot - Q7Z3B4
swissprot - D6RFI8
swissprot - D6RAH0
swissprot - D6RB65
swissprot - D6RBF7
Ensembl - ENSG00000138750
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CZQB01146713.1ENSDARG00000111699Danio rerio
 nup54ENSDARG00000103296Danio rerio
 NUP54ENSGALG00000011506Gallus gallus
 Nup54ENSMUSG00000034826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024864  Nucleoporin Nup54/Nup57/Nup44
 IPR025712  Nucleoporin Nup54, alpha-helical domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006110 regulation of glycolytic process TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006409 tRNA export from nucleus TAS
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IBA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0006999 nuclear pore organization IBA
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process TAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0019083 viral transcription TAS
 biological_processGO:0036228 protein localization to nuclear inner membrane IBA
 biological_processGO:0042306 regulation of protein import into nucleus IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:0070208 protein heterotrimerization IEA
 biological_processGO:0075733 intracellular transport of virus TAS
 biological_processGO:1900034 regulation of cellular response to heat TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0044613 nuclear pore central transport channel IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017056 structural constituent of nuclear pore IBA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
tRNA processing in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138750 NUP54 / Q7Z3B4 / nucleoporin 54  / complex
 ENSG00000213024 NUP62 / P37198 / nucleoporin 62  / complex
 ENSG00000139496 NUP58 / Q9BVL2 / nucleoporin 58  / complex






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr