ENSG00000140396


Homo sapiens

Features
Gene ID: ENSG00000140396
  
Biological name :NCOA2
  
Synonyms : NCOA2 / nuclear receptor coactivator 2 / Q15596
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q13.3
Gene start: 70109762
Gene end: 70403805
  
Corresponding Affymetrix probe sets: 205731_s_at (Human Genome U133 Plus 2.0 Array)   205732_s_at (Human Genome U133 Plus 2.0 Array)   212867_at (Human Genome U133 Plus 2.0 Array)   215605_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430850
Ensembl peptide - ENSP00000399968
Ensembl peptide - ENSP00000429132
Ensembl peptide - ENSP00000430148
Ensembl peptide - ENSP00000430348
NCBI entrez gene - 10499     See in Manteia.
OMIM - 601993
RefSeq - XM_017012973
RefSeq - XM_017012962
RefSeq - XM_017012963
RefSeq - XM_017012964
RefSeq - XM_017012965
RefSeq - XM_017012966
RefSeq - XM_017012967
RefSeq - XM_017012968
RefSeq - XM_017012969
RefSeq - XM_017012970
RefSeq - XM_017012971
RefSeq - XM_017012972
RefSeq - NM_001321703
RefSeq - NM_001321707
RefSeq - NM_001321711
RefSeq - NM_001321712
RefSeq - NM_001321713
RefSeq - NM_006540
RefSeq - XM_017012961
RefSeq Peptide - NP_001308636
RefSeq Peptide - NP_001308640
RefSeq Peptide - NP_001308641
RefSeq Peptide - NP_001308642
RefSeq Peptide - NP_006531
RefSeq Peptide - NP_001308632
swissprot - E5RFN9
swissprot - H0YBB6
swissprot - E7EWM1
swissprot - Q15596
swissprot - A0A1D5RMT0
Ensembl - ENSG00000140396
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncoa2ENSDARG00000017929Danio rerio
 ENSGALG00000036017Gallus gallus
 ENSGALG00000045995Gallus gallus
 Ncoa2ENSMUSG00000005886Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCOA3 / Q9Y6Q9 / nuclear receptor coactivator 3ENSG0000012415142
NCOA1 / Q15788 / nuclear receptor coactivator 1ENSG0000008467636


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010011  Domain of unknown function DUF1518
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR014920  Nuclear receptor coactivator, Ncoa-type, interlocking
 IPR014935  Nuclear receptor coactivator, receptor-binding domain
 IPR017426  Nuclear receptor coactivator
 IPR028822  Nuclear receptor coactivator 2
 IPR032565  Domain of unknown function DUF4927
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily
 IPR037077  Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0015721 bile acid and bile salt transport TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0030522 intracellular receptor signaling pathway IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0045475 locomotor rhythm IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1904017 cellular response to Thyroglobulin triiodothyronine IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016922 nuclear receptor binding IPI
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0030375 thyroid hormone receptor coactivator activity IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
HATs acetylate histones
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000012504 NR1H4 / Q96RI1 / nuclear receptor subfamily 1 group H member 4  / complex / reaction
 ENSG00000123143 PKN1 / Q16512 / protein kinase N1  / reaction / complex
 ENSG00000083168 KAT6A / Q92794 / lysine acetyltransferase 6A  / reaction / complex
 ENSG00000084676 NCOA1 / Q15788 / nuclear receptor coactivator 1  / complex / reaction
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / reaction / complex
 ENSG00000169083 AR / P10275 / androgen receptor  / reaction / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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