ENSG00000141568


Homo sapiens

Features
Gene ID: ENSG00000141568
  
Biological name :FOXK2
  
Synonyms : forkhead box K2 / FOXK2 / Q01167
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q25.3
Gene start: 82519713
Gene end: 82644662
  
Corresponding Affymetrix probe sets: 203064_s_at (Human Genome U133 Plus 2.0 Array)   226224_at (Human Genome U133 Plus 2.0 Array)   242937_at (Human Genome U133 Plus 2.0 Array)   242938_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433167
Ensembl peptide - ENSP00000461540
Ensembl peptide - ENSP00000436108
Ensembl peptide - ENSP00000335677
Ensembl peptide - ENSP00000432663
NCBI entrez gene - 3607     See in Manteia.
OMIM - 147685
RefSeq - NM_004514
RefSeq Peptide - NP_004505
swissprot - E9PPI7
swissprot - E9PM37
swissprot - I3L4U8
swissprot - Q01167
Ensembl - ENSG00000141568
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxk2ENSDARG00000030583Danio rerio
 si:ch211-262e15.1ENSDARG00000011609Danio rerio
 FOXK2ENSGALG00000001577Gallus gallus
 Foxk2ENSMUSG00000039275Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXK1 / P85037 / forkhead box K1ENSG0000016491653
FOXJ3 / Q9UPW0 / forkhead box J3ENSG0000019881516
FOXN4 / Q96NZ1 / forkhead box N4ENSG0000013944515
FOXN2 / P32314 / forkhead box N2ENSG0000017080215
FOXJ2 / Q9P0K8 / forkhead box J2ENSG0000006597015
FOXN3 / O00409 / forkhead box N3ENSG0000005325415
FOXJ1 / Q92949 / forkhead box J1ENSG0000012965414
FOXN1 / O15353 / forkhead box N1ENSG0000010910113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001766  Fork head domain
 IPR008984  SMAD/FHA domain superfamily
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
UCH proteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100811 YY1 / P25490 / YY1 transcription factor  / complex
 ENSG00000171456 ASXL1 / Q8IXJ9 / additional sex combs like 1, transcriptional regulator  / complex
 ENSG00000163930 BAP1 / Q92560 / BRCA1 associated protein 1  / complex / reaction
 ENSG00000147162 OGT / O15294 / O-linked N-acetylglucosamine (GlcNAc) transferase  / complex
 ENSG00000172534 HCFC1 / P51610 / host cell factor C1  / complex
 ENSG00000143970 ASXL2 / Q76L83 / additional sex combs like 2, transcriptional regulator  / complex






 

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