ENSG00000143393


Homo sapiens

Features
Gene ID: ENSG00000143393
  
Biological name :PI4KB
  
Synonyms : phosphatidylinositol 4-kinase beta / PI4KB / Q9UBF8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 151291797
Gene end: 151327715
  
Corresponding Affymetrix probe sets: 206138_s_at (Human Genome U133 Plus 2.0 Array)   206139_at (Human Genome U133 Plus 2.0 Array)   210417_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410974
Ensembl peptide - ENSP00000394719
Ensembl peptide - ENSP00000413599
Ensembl peptide - ENSP00000433149
Ensembl peptide - ENSP00000432426
Ensembl peptide - ENSP00000431501
Ensembl peptide - ENSP00000357866
Ensembl peptide - ENSP00000357867
Ensembl peptide - ENSP00000357868
Ensembl peptide - ENSP00000357869
Ensembl peptide - ENSP00000391546
NCBI entrez gene - 5298     See in Manteia.
OMIM - 602758
RefSeq - XM_017001492
RefSeq - NM_002651
RefSeq - XM_005245264
RefSeq - XM_011509634
RefSeq - XM_011509635
RefSeq - XM_011509636
RefSeq - XM_011509637
RefSeq - XM_011509638
RefSeq - XM_017001486
RefSeq - XM_017001487
RefSeq - XM_017001488
RefSeq - XM_017001489
RefSeq - XM_017001490
RefSeq - XM_017001491
RefSeq - NM_001198773
RefSeq - NM_001198774
RefSeq - NM_001198775
RefSeq Peptide - NP_001185704
RefSeq Peptide - NP_001317650
RefSeq Peptide - NP_002642
RefSeq Peptide - NP_001185702
RefSeq Peptide - NP_001185703
swissprot - H0YCW3
swissprot - A0A0A0MSL0
swissprot - E9PL47
swissprot - Q9UBF8
swissprot - A6PVV8
swissprot - A0A0B4J1S8
swissprot - F8W860
swissprot - H0Y4F8
Ensembl - ENSG00000143393
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pi4kbENSDARG00000040111Danio rerio
 PI4KBENSGALG00000024034Gallus gallus
 Pi4kbENSMUSG00000038861Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0030867 rough endoplasmic reticulum membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004430 1-phosphatidylinositol 4-kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0071889 14-3-3 protein binding IDA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the Golgi membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134287 ARF3 / P61204 / ADP ribosylation factor 3  / complex / reaction
 ENSG00000143761 ARF1 / P84077 / ADP ribosylation factor 1  / complex / reaction






 

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contact: otassy@igbmc.fr