ENSG00000143870


Homo sapiens

Features
Gene ID: ENSG00000143870
  
Biological name :PDIA6
  
Synonyms : PDIA6 / protein disulfide isomerase family A member 6 / Q15084
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p25.1
Gene start: 10783391
Gene end: 10837977
  
Corresponding Affymetrix probe sets: 207668_x_at (Human Genome U133 Plus 2.0 Array)   208638_at (Human Genome U133 Plus 2.0 Array)   208639_x_at (Human Genome U133 Plus 2.0 Array)   216640_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438778
Ensembl peptide - ENSP00000389558
Ensembl peptide - ENSP00000481892
Ensembl peptide - ENSP00000272227
Ensembl peptide - ENSP00000371024
Ensembl peptide - ENSP00000384459
Ensembl peptide - ENSP00000385385
NCBI entrez gene - 10130     See in Manteia.
OMIM - 611099
RefSeq - XM_011510308
RefSeq - NM_001282704
RefSeq - NM_001282705
RefSeq - NM_001282706
RefSeq - NM_001282707
RefSeq - NM_005742
RefSeq Peptide - NP_001269633
RefSeq Peptide - NP_001269634
RefSeq Peptide - NP_001269635
RefSeq Peptide - NP_001269636
RefSeq Peptide - NP_005733
swissprot - Q15084
swissprot - C9JNG5
Ensembl - ENSG00000143870
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdia6ENSDARG00000009001Danio rerio
 PDIA6ENSGALG00000016447Gallus gallus
 Pdia6ENSMUSG00000020571Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IXB1 / DNAJC10 / DnaJ heat shock protein family (Hsp40) member C10ENSG0000007723221
PDIA5 / Q14554 / protein disulfide isomerase family A member 5ENSG0000006548520
Q8NBS9 / TXNDC5 / thioredoxin domain containing 5ENSG0000023926420


Protein motifs (from Interpro)
Interpro ID Name
 IPR005788  Disulphide isomerase
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0034976 response to endoplasmic reticulum stress IBA
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0043277 apoptotic cell clearance IBA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex ISS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003756 protein disulfide isomerase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015037 peptide disulfide oxidoreductase activity IDA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
XBP1(S) activates chaperone genes
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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