ENSG00000145423


Homo sapiens

Features
Gene ID: ENSG00000145423
  
Biological name :SFRP2
  
Synonyms : Q96HF1 / secreted frizzled related protein 2 / SFRP2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q31.3
Gene start: 153780592
Gene end: 153789120
  
Corresponding Affymetrix probe sets: 223121_s_at (Human Genome U133 Plus 2.0 Array)   223122_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274063
NCBI entrez gene - 6423     See in Manteia.
OMIM - 604157
RefSeq - NM_003013
RefSeq Peptide - NP_003004
swissprot - A0A140VJU3
swissprot - Q96HF1
Ensembl - ENSG00000145423
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sfrp2ENSDARG00000070050Danio rerio
 SFRP2ENSGALG00000009241Gallus gallus
 Sfrp2ENSMUSG00000027996Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SFRP5 / Q5T4F7 / secreted frizzled related protein 5ENSG0000012005742
SFRP1 / Q8N474 / secreted frizzled related protein 1ENSG0000010433240
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876326
FZD1 / Q9UP38 / frizzled class receptor 1ENSG0000015724025
FZD8 / Q9H461 / frizzled class receptor 8ENSG0000017728325
FZD10 / Q9ULW2 / frizzled class receptor 10ENSG0000011143224
FZD5 / Q13467 / frizzled class receptor 5ENSG0000016325124
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034023
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480423
FZD7 / O75084 / frizzled class receptor 7ENSG0000015576023
FZD3 / Q9NPG1 / frizzled class receptor 3ENSG0000010429021
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493021
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860216
FRZB / Q92765 / frizzled related proteinENSG0000016299815
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR026558  Secreted frizzled-related protein 2
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis ISS
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0002063 chondrocyte development IEA
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003214 cardiac left ventricle morphogenesis IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IDA
 biological_processGO:0010950 positive regulation of endopeptidase activity IEA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway NAS
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030307 positive regulation of cell growth ISS
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISS
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin ISS
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0036342 post-anal tail morphogenesis IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042662 negative regulation of mesodermal cell fate specification IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046546 development of primary male sexual characteristics IEA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IDA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060028 convergent extension involved in axis elongation IEA
 biological_processGO:0060349 bone morphogenesis IEA
 biological_processGO:0061056 sclerotome development ISS
 biological_processGO:0061185 negative regulation of dermatome development ISS
 biological_processGO:0071425 hematopoietic stem cell proliferation ISS
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090175 regulation of establishment of planar polarity IEA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IEA
 biological_processGO:0090244 Wnt signaling pathway involved in somitogenesis IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISS
 biological_processGO:1904956 regulation of midbrain dopaminergic neuron differentiation IEA
 biological_processGO:2000035 regulation of stem cell division ISS
 biological_processGO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0031012 extracellular matrix ISS
 molecular_functionGO:0001968 fibronectin binding ISS
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005178 integrin binding ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA
 molecular_functionGO:0048018 receptor ligand activity ISS
 molecular_functionGO:0061133 endopeptidase activator activity IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154342 WNT3A / P56704 / Wnt family member 3A  / complex / reaction






 

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