ENSG00000148943


Homo sapiens

Features
Gene ID: ENSG00000148943
  
Biological name :LIN7C
  
Synonyms : LIN7C / lin-7 homolog C, crumbs cell polarity complex component / Q9NUP9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p14.1
Gene start: 27494576
Gene end: 27506773
  
Corresponding Affymetrix probe sets: 219399_at (Human Genome U133 Plus 2.0 Array)   221568_s_at (Human Genome U133 Plus 2.0 Array)   223350_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000278193
Ensembl peptide - ENSP00000435353
NCBI entrez gene - 55327     See in Manteia.
OMIM - 612332
RefSeq - NM_018362
RefSeq Peptide - NP_060832
swissprot - Q9NUP9
swissprot - G3V1D4
Ensembl - ENSG00000148943
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIN7CENSGALG00000012170Gallus gallus
 C ENSMUSG00000027162Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LIN7B / Q9HAP6 / lin-7 homolog B, crumbs cell polarity complex componentENSG0000010486384
LIN7A / O14910 / lin-7 homolog A, crumbs cell polarity complex componentENSG0000011105280
SNTB1 / Q13884 / syntrophin beta 1ENSG0000017216428
GOPC / Q9HD26 / golgi associated PDZ and coiled-coil motif containingENSG0000004793228
SNTB2 / Q13425 / syntrophin beta 2ENSG0000016880727
SNTG2 / Q9NY99 / syntrophin gamma 2ENSG0000017255425
SNTA1 / Q13424 / syntrophin alpha 1ENSG0000010140024
AL132671.2ENSG0000028221823
SNTG1 / Q9NSN8 / syntrophin gamma 1ENSG0000014748120


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR014775  L27 domain, C-terminal
 IPR017365  Protein lin-7
 IPR036034  PDZ superfamily
 IPR036892  L27 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002011 morphogenesis of an epithelial sheet IMP
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007269 neurotransmitter secretion IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:1903361 protein localization to basolateral plasma membrane IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097025 MPP7-DLG1-LIN7 complex IDA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0097016 L27 domain binding IDA


Pathways (from Reactome)
Pathway description
Dopamine Neurotransmitter Release Cycle
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107282 APBA1 / Q02410 / amyloid beta precursor protein binding family A member 1  / reaction / complex
 ENSG00000147044 CASK / O14936 / calcium/calmodulin dependent serine protein kinase  / complex / reaction






 

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