ENSG00000155363


Homo sapiens

Features
Gene ID: ENSG00000155363
  
Biological name :MOV10
  
Synonyms : MOV10 / Mov10 RISC complex RNA helicase / Q9HCE1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.2
Gene start: 112673141
Gene end: 112700746
  
Corresponding Affymetrix probe sets: 223849_s_at (Human Genome U133 Plus 2.0 Array)   233917_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000350028
Ensembl peptide - ENSP00000358658
Ensembl peptide - ENSP00000358659
Ensembl peptide - ENSP00000399797
NCBI entrez gene - 4343     See in Manteia.
OMIM - 610742
RefSeq - XM_017001319
RefSeq - NM_001130079
RefSeq - NM_001286072
RefSeq - NM_001321324
RefSeq - NM_020963
RefSeq - XM_005270869
RefSeq - XM_005270870
RefSeq - XM_017001318
RefSeq Peptide - NP_001123551
RefSeq Peptide - NP_001273001
RefSeq Peptide - NP_001308253
RefSeq Peptide - NP_066014
swissprot - Q5JR04
swissprot - Q9HCE1
Ensembl - ENSG00000155363
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mov10aENSDARG00000015829Danio rerio
 Q1LXK4ENSDARG00000061177Danio rerio
 Q1LXK5ENSDARG00000056065Danio rerio
 MOV10ENSGALG00000001558Gallus gallus
 Mov10ENSMUSG00000002227Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BXT6 / MOV10L1 / Mov10 RISC complex RNA helicase like 1ENSG0000007314632
HELZ / P42694 / helicase with zinc fingerENSG0000019826520
UPF1 / Q92900 / UPF1, RNA helicase and ATPaseENSG0000000500718
HELZ2 / Q9BYK8 / helicase with zinc finger 2ENSG0000013058918


Protein motifs (from Interpro)
Interpro ID Name
 IPR026122  Putative helicase MOV-10
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0035195 gene silencing by miRNA IMP
 biological_processGO:0035279 mRNA cleavage involved in gene silencing by miRNA IDA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ca2+ pathway
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123908 AGO2 / Q9UKV8 / argonaute 2, RISC catalytic component  / complex
 ENSG00000126070 AGO3 / Q9H9G7 / argonaute 3, RISC catalytic component  / complex
 ENSG00000100354 Q9UPQ9 / TNRC6B / trinucleotide repeat containing 6B  / complex
 ENSG00000078687 Q9HCJ0 / TNRC6C / trinucleotide repeat containing 6C  / complex
 ENSG00000090905 Q8NDV7 / TNRC6A / trinucleotide repeat containing 6A  / complex
 ENSG00000092847 AGO1 / Q9UL18 / argonaute 1, RISC catalytic component  / complex
 ENSG00000134698 AGO4 / Q9HCK5 / argonaute 4, RISC catalytic component  / complex






 

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