ENSG00000158402


Homo sapiens

Features
Gene ID: ENSG00000158402
  
Biological name :CDC25C
  
Synonyms : CDC25C / cell division cycle 25C / P30307
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.2
Gene start: 138285265
Gene end: 138338355
  
Corresponding Affymetrix probe sets: 205167_s_at (Human Genome U133 Plus 2.0 Array)   216914_at (Human Genome U133 Plus 2.0 Array)   217010_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425470
Ensembl peptide - ENSP00000424795
Ensembl peptide - ENSP00000427105
Ensembl peptide - ENSP00000427251
Ensembl peptide - ENSP00000321656
Ensembl peptide - ENSP00000345205
Ensembl peptide - ENSP00000392631
Ensembl peptide - ENSP00000423525
NCBI entrez gene - 995     See in Manteia.
OMIM - 157680
RefSeq - XM_017010101
RefSeq - NM_022809
RefSeq - XM_005272145
RefSeq - XM_006714739
RefSeq - XM_011543759
RefSeq - XM_011543760
RefSeq - XM_011543761
RefSeq - XM_011543762
RefSeq - XM_011543763
RefSeq - XM_011543764
RefSeq - NM_001287582
RefSeq - NM_001287583
RefSeq - NM_001318098
RefSeq - NM_001790
RefSeq Peptide - NP_001274512
RefSeq Peptide - NP_001305027
RefSeq Peptide - NP_001781
RefSeq Peptide - NP_073720
RefSeq Peptide - NP_001274511
swissprot - H0Y999
swissprot - P30307
swissprot - D6RD20
swissprot - D6RJC2
Ensembl - ENSG00000158402
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Cdc25cENSMUSG00000044201Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDC25B / P30305 / cell division cycle 25BENSG0000010122436
CDC25A / P30304 / cell division cycle 25AENSG0000016404534


Protein motifs (from Interpro)
Interpro ID Name
 IPR000751  M-phase inducer phosphatase
 IPR001763  Rhodanese-like domain
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IGI
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007088 regulation of mitotic nuclear division TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:1902751 positive regulation of cell cycle G2/M phase transition IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity TAS
 molecular_functionGO:0004725 protein tyrosine phosphatase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0050699 WW domain binding IPI


Pathways (from Reactome)
Pathway description
Polo-like kinase mediated events
Activation of ATR in response to replication stress
RHO GTPases activate PKNs
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Cyclin A/B1/B2 associated events during G2/M transition
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123143 PKN1 / Q16512 / protein kinase N1  / reaction / complex
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction
 ENSG00000149554 CHEK1 / O14757 / checkpoint kinase 1  / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000108953 YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon  / complex / reaction
 ENSG00000183765 CHEK2 / O96017 / checkpoint kinase 2  / reaction
 ENSG00000173846 PLK3 / Q9H4B4 / polo like kinase 3  / reaction






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr