ENSG00000163251


Homo sapiens

Features
Gene ID: ENSG00000163251
  
Biological name :FZD5
  
Synonyms : frizzled class receptor 5 / FZD5 / Q13467
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q33.3
Gene start: 207762586
Gene end: 207769563
  
Corresponding Affymetrix probe sets: 206136_at (Human Genome U133 Plus 2.0 Array)   221245_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354607
NCBI entrez gene - 7855     See in Manteia.
OMIM - 601723
RefSeq - NM_003468
RefSeq Peptide - NP_003459
swissprot - Q13467
Ensembl - ENSG00000163251
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd5ENSDARG00000025420Danio rerio
 FZD5ENSGALG00000034101Gallus gallus
 Fzd5ENSMUSG00000045005Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZD8 / Q9H461 / frizzled class receptor 8ENSG0000017728370
FZD1 / Q9UP38 / frizzled class receptor 1ENSG0000015724046
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034046
FZD7 / O75084 / frizzled class receptor 7ENSG0000015576046
FZD10 / Q9ULW2 / frizzled class receptor 10ENSG0000011143243
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876342
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480440
FZD3 / Q9NPG1 / frizzled class receptor 3ENSG0000010429036
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493035
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860225
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648317
FRZB / Q92765 / frizzled related proteinENSG0000016299814
SFRP1 / Q8N474 / secreted frizzled related protein 1ENSG0000010433213
SFRP5 / Q5T4F7 / secreted frizzled related protein 5ENSG0000012005713
SFRP2 / Q96HF1 / secreted frizzled related protein 2ENSG0000014542312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR036790  Frizzled cysteine-rich domain superfamily
 IPR037441  Frizzled-5, CRD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000578 embryonic axis specification IDA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0002726 positive regulation of T cell cytokine production IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007416 synapse assembly TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008595 anterior/posterior axis specification, embryo IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0031076 embryonic camera-type eye development IEA
 biological_processGO:0031077 post-embryonic camera-type eye development IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0060061 Spemann organizer formation IDA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0060561 apoptotic process involved in morphogenesis IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IEA
 biological_processGO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0060718 chorionic trophoblast cell differentiation IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0071219 cellular response to molecule of bacterial origin IDA
 biological_processGO:1901382 regulation of chorionic trophoblast cell proliferation IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IEA
 biological_processGO:1904886 beta-catenin destruction complex disassembly TAS
 biological_processGO:2000810 regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0106003 amyloid-beta complex IPI
 molecular_functionGO:0001540 amyloid-beta binding TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0017147 Wnt-protein binding TAS
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042813 Wnt-activated receptor activity IDA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
Ca2+ pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
RNF mutants show enhanced WNT signaling and proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114251 WNT5A / P41221 / Wnt family member 5A  / complex / reaction






 

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