ENSG00000163466


Homo sapiens

Features
Gene ID: ENSG00000163466
  
Biological name :ARPC2
  
Synonyms : actin related protein 2/3 complex subunit 2 / ARPC2 / O15144
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q35
Gene start: 218217094
Gene end: 218254356
  
Corresponding Affymetrix probe sets: 207988_s_at (Human Genome U133 Plus 2.0 Array)   208679_s_at (Human Genome U133 Plus 2.0 Array)   213513_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411612
Ensembl peptide - ENSP00000401070
Ensembl peptide - ENSP00000412632
Ensembl peptide - ENSP00000295685
Ensembl peptide - ENSP00000327137
Ensembl peptide - ENSP00000396475
NCBI entrez gene - 10109     See in Manteia.
OMIM - 604224
RefSeq - XM_017003115
RefSeq - NM_005731
RefSeq - NM_152862
RefSeq - XM_017003113
RefSeq - XM_017003114
RefSeq Peptide - NP_690601
RefSeq Peptide - NP_005722
swissprot - G5E9J0
swissprot - G5E9S7
swissprot - H7C3F9
swissprot - C9JTV5
swissprot - Q53R19
swissprot - O15144
Ensembl - ENSG00000163466
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arpc2ENSDARG00000075989Danio rerio
 ARPC2ENSGALG00000011452Gallus gallus
 Arpc2ENSMUSG00000006304Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007188  Actin-related protein 2/3 complex subunit 2
 IPR034666  Arp2/3 complex subunit 2/4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010592 positive regulation of lamellipodium assembly IMP
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0070358 actin polymerization-dependent cell motility TAS
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005885 Arp2/3 protein complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0036195 muscle cell projection membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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