ENSG00000166167


Homo sapiens

Features
Gene ID: ENSG00000166167
  
Biological name :BTRC
  
Synonyms : beta-transducin repeat containing E3 ubiquitin protein ligase / BTRC / Q9Y297
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q24.32
Gene start: 101354033
Gene end: 101557321
  
Corresponding Affymetrix probe sets: 1563620_at (Human Genome U133 Plus 2.0 Array)   204901_at (Human Genome U133 Plus 2.0 Array)   216091_s_at (Human Genome U133 Plus 2.0 Array)   222374_at (Human Genome U133 Plus 2.0 Array)   224471_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377088
Ensembl peptide - ENSP00000385339
Ensembl peptide - ENSP00000359202
Ensembl peptide - ENSP00000359206
NCBI entrez gene - 8945     See in Manteia.
OMIM - 603482
RefSeq - XM_017016874
RefSeq - NM_033637
RefSeq - XM_006718054
RefSeq - XM_011540320
RefSeq - XM_017016870
RefSeq - XM_017016871
RefSeq - XM_017016872
RefSeq - XM_017016873
RefSeq - NM_001256856
RefSeq - NM_003939
RefSeq Peptide - NP_001243785
RefSeq Peptide - NP_003930
RefSeq Peptide - NP_378663
swissprot - B7Z3H4
swissprot - A0A0S2Z4P6
swissprot - Q5T1W7
swissprot - Q9Y297
Ensembl - ENSG00000166167
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BTRCENSGALG00000007820Gallus gallus
 BtrcENSMUSG00000025217Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11ENSG0000007280376
FBXW7 / Q969H0 / F-box and WD repeat domain containing 7ENSG0000010967025
Q9H2Y7 / ZNF106 / zinc finger protein 106ENSG0000010399422
TRAF7 / Q6Q0C0 / TNF receptor associated factor 7ENSG0000013165319
FBXW10 / Q5XX13 / F-box and WD repeat domain containing 10ENSG0000017193117
CDRT1 / O95170 / CMT1A duplicated region transcript 1ENSG0000024132216
FBXW2 / Q9UKT8 / F-box and WD repeat domain containing 2ENSG0000011940215
WDR86 / Q86TI4 / WD repeat domain 86ENSG0000018726014


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR021977  D domain of beta-TrCP
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006470 protein dephosphorylation ISS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042752 regulation of circadian rhythm IDA
 biological_processGO:0042753 positive regulation of circadian rhythm ISS
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045862 positive regulation of proteolysis IMP
 biological_processGO:0045879 negative regulation of smoothened signaling pathway TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051403 stress-activated MAPK cascade TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IC
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0045309 protein phosphorylated amino acid binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Deactivation of the beta-catenin transactivating complex
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
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 HP:0000526 Aniridia "Congenital absence of the iris." [HPO:curators]
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 HP:0001171 Ectrodactyly (hands) 
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 HP:0004050 Absent hands 
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 HP:0006101 Finger syndactyly "Webbing or fusion of the fingers, involving soft parts only or including bone structure. Bony fusions are revered to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers in a proximo-distal axis are refered to as "Symphalangism"." [HPO:curators]
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 HP:0012165 Oligodactyly "A developmental defect resulting in the presence of fewer than the normal number of digits." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000104856 RELB / Q01201 / RELB proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000134982 APC / P25054 / APC, WNT signaling pathway regulator  / complex
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / reaction / complex
 ENSG00000159692 CTBP1 / Q13363 / C-terminal binding protein 1  / complex
 ENSG00000168884 TNIP2 / Q8NFZ5 / TNFAIP3 interacting protein 2  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction / complex
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / complex / reaction
 ENSG00000146232 NFKBIE / O00221 / NFKB inhibitor epsilon  / complex / reaction
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / complex / reaction
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / reaction / complex
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / complex / reaction
 ENSG00000179094 PER1 / O15534 / period circadian regulator 1  / reaction / complex
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / reaction / complex
 ENSG00000132326 PER2 / O15055 / period circadian regulator 2  / complex / reaction
 ENSG00000104825 NFKBIB / Q15653 / NFKB inhibitor beta  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000162924 REL / Q04864 / REL proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / reaction / complex
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000172179 PRL / P01236 / prolactin  / complex / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction






 

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