ENSG00000166226


Homo sapiens

Features
Gene ID: ENSG00000166226
  
Biological name :CCT2
  
Synonyms : CCT2 / chaperonin containing TCP1 subunit 2 / P78371
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q15
Gene start: 69585334
Gene end: 69601570
  
Corresponding Affymetrix probe sets: 201946_s_at (Human Genome U133 Plus 2.0 Array)   201947_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000299300
Ensembl peptide - ENSP00000441847
Ensembl peptide - ENSP00000445471
Ensembl peptide - ENSP00000450153
NCBI entrez gene - 10576     See in Manteia.
OMIM - 605139
RefSeq - NM_006431
RefSeq - NM_001198842
RefSeq Peptide - NP_001185771
RefSeq Peptide - NP_006422
swissprot - V9HW96
swissprot - F5GWF6
swissprot - F8VQ14
swissprot - P78371
Ensembl - ENSG00000166226
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCT2ENSDARG00000104674Danio rerio
 CCT2ENSGALG00000009975Gallus gallus
 Cct2ENSMUSG00000034024Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002194  Chaperonin TCP-1, conserved site
 IPR002423  Chaperonin Cpn60/TCP-1 family
 IPR012716  T-complex protein 1, beta subunit
 IPR017998  Chaperone tailless complex polypeptide 1 (TCP-1)
 IPR027409  GroEL-like apical domain superfamily
 IPR027413  GroEL-like equatorial domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding NAS
 biological_processGO:0007339 binding of sperm to zona pellucida IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051086 chaperone mediated protein folding independent of cofactor IMP
 biological_processGO:0051131 chaperone-mediated protein complex assembly IMP
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0090666 scaRNA localization to Cajal body IMP
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1904851 positive regulation of establishment of protein localization to telomere IMP
 biological_processGO:1904871 positive regulation of protein localization to Cajal body IMP
 biological_processGO:1904874 positive regulation of telomerase RNA localization to Cajal body IMP
 cellular_componentGO:0002199 zona pellucida receptor complex IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005832 chaperonin-containing T-complex IDA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0044183 protein binding involved in protein folding IPI
 molecular_functionGO:0051082 unfolded protein binding IBA


Pathways (from Reactome)
Pathway description
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Folding of actin by CCT/TriC
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Neutrophil degranulation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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